背景:瘦素在结核病(TB)的能量和炎症调节中起关键作用。然而,其在儿童结核病中的相关性尚不清楚.因此,这项研究旨在评估身体质量指数之间的相关性,IFN-γ,TNF-α,结核病儿童的瘦素水平。
方法:这是一项针对2-14岁结核病儿童的横断面研究。痰检,胸部X线摄影术,结核菌素皮肤试验结果和临床症状被考虑用于结核病诊断。体重数据;身高;上臂中围(MUAC);体重指数(BMI);食物摄入量;和IFN-γ,TNF-α,收集和分析瘦素水平。
结果:在64名确诊的结核病患者中,2名受试者的细菌学结果为阳性。中位年龄为6(2-14)岁,体重为17.7(9.45-55)kg,身高114±21.46厘米,Z评分BMI为-0.85±1.14kg/m2。在17.2%的受试者中观察到营养不良。卡路里摄入量中位数为1448.5(676-4674)千卡,碳水化合物摄入量为182.5(63-558)克,蛋白质摄入量为57.9(15.8-191.0)g,脂肪摄入量为81.6(23.6-594.1)g。瘦素水平中位数为1.2(0.2-59)ng/mL,IFN-γ为2.5(0.9-161)pg/mL,TNF-α为13.0(5.7-356)pg/mL。在瘦素和MUAC之间观察到相关性(r=0.251,p=0.02),Z得分(r=0.453,p=0.00),和IFN-γ(r=0.295,p=0.018)。
结论:BMI与瘦素水平呈正相关,而IFN-γ和MUAC显示弱相关性。
BACKGROUND: Leptin plays a key role in the regulation of energy and inflammation in tuberculosis (TB). However, its correlation in children with TB remains unclear. Therefore, this study aimed to evaluate the correlations between body mass index, IFN-γ, TNF-α, and leptin levels in children with TB.
METHODS: This was a cross-sectional study of children aged 2-14 years with TB. Sputum examination, chest radiography, and tuberculin skin test findings and clinical symptoms were considered for TB diagnosis. Data on body weight; height; mid-upper arm circumference (MUAC); body mass index (BMI); food intake; and IFN-γ, TNF-α, and leptin levels were collected and analyzed.
RESULTS: Of the 64 diagnosed TB subjects, 2 subjects had positive bacteriological results. The median age was 6 (2-14) years, body weight was 17.7 (9.45-55) kg, height was 114 ± 21.46 cm, and Z score BMI was -0.85 ± 1.14 kg/m2. Malnourished was observed in 17.2% of the subjects. The median calorie intake was 1448.5 (676-4674) kcal, carbohydrate intake was 182.5 (63-558) g, protein intake was 57.9 (15.8-191.0) g, and fat intake was 81.6 (23.6-594.1) g. The median leptin level was 1.2 (0.2-59) ng/mL, IFN-γ was 2.5 (0.9-161) pg/mL, and TNF-α was 13.0 (5.7-356) pg/mL. Correlations were observed between leptin and MUAC (r = 0.251, p = 0.02), Z score (r = 0.453, p = 0.00), and IFN-γ (r = 0.295, p = 0.018).
CONCLUSIONS: There were positive correlations between BMI and leptin levels, whereas IFN-γ and MUAC showed weak correlations.