未经证实:TFE3易位肾细胞癌(RCC)是一种罕见的肿瘤,约占RCC的1%。它在2016年被世界卫生组织列为MiT家族易位RCC的成员。其特征在于涉及TFE3的Xp11易位基因融合。TFE3易位RCC的诊断是基于免疫组织化学分析和FISH分析中TFE3分解探针,而不是组织学特征和影像学检查。
未经批准:为了确定临床病理,免疫表型,TFE3易位RCC的细胞遗传学特征。
UNASSIGNED:分析了一名52岁女性TFE3易位RCC患者的临床资料,表现出罕见的形态学特征,用组织病理学染色探测肿瘤组织,免疫组织化学,和荧光原位杂交(FISH)。此外,回顾了相关文献。
UNASSIGNED:该病例为TFE3易位RCC,具有罕见的形态学特征。它由两种类型的肿瘤细胞组成。TFE3和pax-8在两种肿瘤细胞中弥漫性和强表达,它们的CAIX部分呈阳性,RCC,CK,EMA,CD10,Vim,Melan-A,和p504s。只有2%的细胞增殖标志物Ki-67阳性,肿瘤CK7、CD117、抑制素-α阴性,HBM45和p53。FISH显示TFE3易位的阳性信号。
未经证实:该病例为TFE3易位RCC,具有罕见形态学特征。通过这个案例报告,我们强调了原位检测TFE3基因易位和蛋白质在TFE3易位RCC中的重要性。
UNASSIGNED: TFE3 translocation renal cell carcinoma (RCC) is a rare tumor that represents approximately 1% of RCC. It was classifed as a member of MiT family translocation RCCs by the World Health Organization in 2016. It is characterized by Xp11 translocation gene fusions involving TFE3. The diagnosis of TFE3 translocation RCC is based on immunohistochemical analysis and TFE3 break apart probes in FISH analysis, rather than histological characteristics and imaging examination.
UNASSIGNED: To determine the clinico-pathological, immuno-phenotypic, and cytogenetic characteristics of TFE3 translocation RCC.
UNASSIGNED: The clinical data of a 52-year-old-female patient with TFE3 translocation RCC exhibiting rare morphological characteristics was analyzed, and the tumor tissues were probed using histopathological staining, immunohistochemistry, and fluorescence in situ hybridization (FISH). In addition, the relevant literature was reviewed.
UNASSIGNED: This case is a TFE3 translocation RCC with rare morphological features. It composed of two types of tumor cells. TFE3 and pax-8 were diffusely and strongly expressed in both tumor cells, and they were partially positive for CAIX, RCC, CK, EMA, CD10, Vim, Melan-A, and p504s. Only 2% of the cells were positive for the proliferation marker Ki-67, and the tumor was negative for CK7, CD117, Inhibin-α, HBM45, and p53. FISH showed a positive signal for TFE3 translocation.
UNASSIGNED: This case was a TFE3 translocation RCC with rare morphological features. Through this case report, we emphasize the importance of in situ detection of TFE3 gene translocation and protein in TFE3 translocation RCC.