■血小板参数的变化可能因病原体的不同而不同。然而,对于重症社区获得性肺炎(CAP)患儿的病毒和细菌感染的血小板参数差异知之甚少.
■这是一项单中心回顾性研究,纳入了156例重度CAP患儿。血小板参数的动态变化,包括血小板计数(PLT),平均血小板体积(MPV),血小板分布宽度(PDW)和血小板聚集(PCT),在24小时记录,48h,72小时,入院的第七天,以及在出院时。
■入院72小时时,病毒感染组PLT明显低于细菌感染和细菌与病毒共感染组。同时,在此时间点,病毒感染组的PLT(ΔPLT)变化曲线与其他两组明显分开。受试者工作特征(ROC)分析显示,入院72h的PLT有助于区分重症肺炎患儿的细菌和病毒感染,曲线下面积(AUC)值为0.683[95%置信区间(CI):0.561-0.805,P=0.007]。然而,其敏感性和特异性不高,68%和65%,分别。
■尽管血小板参数对重度CAP患儿细菌和病毒感染的诊断价值有限,仍有望与其他指标相结合,为及时治疗提供参考。
UNASSIGNED: Changes in platelet parameters may vary according to the different pathogens. However, little is known about the differences in platelet parameters in children with severe community-acquired pneumonia (CAP) children of viral and bacterial infections.
UNASSIGNED: This was a single-center retrospective study that included 156 children with severe CAP. Dynamic changes in platelet parameters, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT), were recorded at 24 h, 48 h, 72 h, and day 7 of admission, as well as at discharge.
UNASSIGNED: At 72 h of admission, PLT in the viral infection group was significantly lower than that in the bacterial infection and bacterial and viral coinfections group. Meanwhile, the curve of changes in PLT (ΔPLT) in the viral infection group was clearly separated from the other two groups at this time point. Receiver operating characteristic (ROC) analysis showed that PLT at 72 h of admission could assist in distinguishing bacterial and viral infections in severe pneumonia children with the area under curve (AUC) value of 0.683 [95% confidence interval (CI): 0.561-0.805, P=0.007]. However, its sensitivity and specificity were not high, at 68% and 65%, respectively.
UNASSIGNED: Although the diagnostic value of platelet parameters in bacterial and viral infection in children with severe CAP is limited, they are still expected to be combined with other indicators to provide a reference for timely treatment.