糖尿病肾病(DN)和糖尿病视网膜病变(DR),作为糖尿病的微血管并发症,目前是终末期肾病(ESRD)和失明的主要原因,分别,在成年劳动人口中,它们是具有社会和经济负担的重大公共卫生问题。两者在发生发展过程中的平行性表现为致病危险因素和发病机制的高度重叠,高合并症发生率,相互预测的效果,和临床用药的部分一致性。然而,因为这两个器官,眼睛和肾脏,有其独特的内部环境和生理过程,每个都有特定的影响分子,由于不同的病理改变和对各种影响因素的反应,靶器官具有非平行性,本文对DN和DR的平行性和不平行性进行了概述,以进一步认识两种疾病的共同点和区别,为早期诊断提供参考。使用药物的临床指导,以及新药的开发。
Diabetic nephropathy (DN) and diabetic retinopathy (DR), as microvascular complications of diabetes mellitus, are currently the leading causes of end-stage renal disease (ESRD) and blindness, respectively, in the adult working population, and they are major public health problems with social and economic burdens. The
parallelism between the two in the process of occurrence and development manifests in the high overlap of disease-causing risk factors and pathogenesis, high rates of comorbidity, mutually predictive effects, and partial concordance in the clinical use of medications. However, since the two organs, the eye and the kidney, have their unique internal environment and physiological processes, each with specific influencing molecules, and the target organs have non-
parallelism due to different pathological changes and responses to various influencing factors, this article provides an overview of the
parallelism and non-
parallelism between DN and DR to further recognize the commonalities and differences between the two diseases and provide references for early diagnosis, clinical guidance on the use of medication, and the development of new drugs.