背景:为了确定患病率,临床特征,和葡萄膜黄斑水肿(UME)的患者的独立预测因子,后部和全葡萄膜炎。
方法:我们回顾性回顾了中间,后部,以及在2015年1月至2020年2月期间使用光学相干断层扫描进行黄斑评估的全葡萄膜炎.描述了UME的患病率和患者的临床特征。使用多元回归分析确定UME的预测因子。
结果:共纳入349例患者。平均年龄是41岁,女性:男性比例为1.3:1。UME的患病率为51.9%。UME占33.9%,56.9%,和54.1%的中间体,后部,和全葡萄膜炎病例,分别。在UME患者中,47%有感染性葡萄膜炎,32.6%患有特发性葡萄膜炎,20.4%患有免疫介导的葡萄膜炎。弥漫性黄斑水肿是最常见的模式(36.5%)。多变量分析显示,与UME独立相关的因素包括葡萄膜炎发病时的年龄(校正比值比[aOR]1.01,95%置信区间[CI]1.00-1.03,P=0.036)。PU和全葡萄膜炎与中度葡萄膜炎相比(aOR2.09,95%CI1.14-3.86,P=0.018),与非感染性葡萄膜炎相比(aOR2.13,95%CI1.34-3.37,P=0.001)。
结论:葡萄膜炎发病年龄增加,后/全葡萄膜炎,感染病因是中度患者UME的预测因素,后部和全葡萄膜炎。
BACKGROUND: To determine the prevalence, clinical characteristics, and independent predictors of uveitic macular edema (UME) in patients with intermediate, posterior and
panuveitis.
METHODS: We retrospectively reviewed the records of patients with intermediate, posterior, and
panuveitis who underwent macular assessment using optical coherence tomography between January 2015 and February 2020. The prevalence of UME and clinical characteristics of the patients were described. Predictors of UME were identified using multivariate regression analysis.
RESULTS: A total of 349 patients were included. The mean age was 41 years, female: male ratio was 1.3:1. The prevalence of UME was 51.9%. UME was found in 33.9%, 56.9%, and 54.1% of the intermediate, posterior, and
panuveitis cases, respectively. Among patients with UME, 47% had infectious uveitis, 32.6% had idiopathic uveitis, and 20.4% had immune-mediated uveitis. Diffuse macular edema was the most frequently observed pattern (36.5%). Multivariate analysis showed that factors independently associated with UME included age at uveitis onset (adjusted odds ratio [aOR] 1.01, 95% confidence interval [CI] 1.00-1.03, P = 0.036), PU and panuveitis compared with intermediate uveitis (aOR 2.09, 95% CI 1.14-3.86, P = 0.018), and infectious uveitis compared with noninfectious uveitis (aOR 2.13, 95% CI 1.34-3.37, P = 0.001).
CONCLUSIONS: Increasing age at uveitis onset, posterior/
panuveitis, and infectious etiology are predictive factors for UME in patients with intermediate, posterior and
panuveitis.