UNASSIGNED:结直肠印戒细胞癌(SRCC)的预后很少受到关注。本研究旨在探讨阳性淋巴结(LODDS)的对数几率的预测能力,淋巴结比率(LNR),和pN分期对结直肠SRCC患者预后的影响。
未经评估:设计了一项回顾性队列研究,从监控中提取数据,流行病学和最终结果(SEER)数据库。关于人口特征的数据,临床病理特征,和治疗被提取。结果是总生存期(OS)和癌症特异性生存期(CSS)。LODDS协会,LNR,使用Cox比例风险模型和Cox竞争风险模型探索了OS和CSS的pN阶段,分别,结果显示为风险比和95%置信区间(CI)。LODDS的预测性能,LNR,通过计算C指数评估OS和CSS中的pN阶段。
未经授权:本研究共纳入2,198例患者。LODDS,LNR,结直肠SRCC患者的OS和CSS与pN分期相关(均P<0.05)。LODDS在操作系统中表现良好(C-index:0.704,95%CI:0.690-0.718),优于LNR(C指数:0.657,95%CI:0.643-0.671)和pN阶段(C指数:0.643,95%CI:0.629-0.657)。LODDS的C指数,LNR,CSS的pN阶段为0.733(95%CI:0.719-0.747),0.713(95%CI:0.697-0.729),和0.667(95%CI:0.651-0.683),分别。
UNASSIGNED:LODDS在OS和CSS中显示出比LNR和pN阶段更好的预测能力,提示LODDS在临床上可有效预测结直肠SRCC的预后。
UNASSIGNED: Little attention has been paid in the prognosis of colorectal signet ring cell carcinoma (SRCC). This study aims to explore the predictive capacity of log odds of positive lymph nodes (LODDS), lymph node ratio (LNR), and pN stage in the prognosis of patients with colorectal SRCC.
UNASSIGNED: A retrospective cohort study was designed, and data were extracted from the Surveillance, Epidemiology and End Results (SEER) database. Data on demographic characteristics, clinicopathological features, and treatment were extracted. Outcomes were overall survival (OS) and cancer-specific survival (CSS). Association of LODDS, LNR, and pN stage with OS and CSS were explored using Cox proportional hazard model and Cox competing risk model, respectively, with results showing as hazard ratio and 95% confidence interval (CI). Predictive performance of LODDS, LNR, and pN stage in OS and CSS was assessed by calculating C-index.
UNASSIGNED: A total of 2,198 patients were included in this study. LODDS, LNR, and pN stage were associated with the OS and CSS of colorectal SRCC patients (all P < 0.05). LODDS showed a good performance in the OS (C-index: 0.704, 95% CI: 0.690-0.718), which was superior to LNR (C-index: 0.657, 95% CI: 0.643-0.671) and pN stage (C-index: 0.643, 95% CI: 0.629-0.657). The C-index of LODDS, LNR, and pN stage for CSS was 0.733 (95% CI: 0.719-0.747), 0.713 (95% CI: 0.697-0.729), and 0.667 (95% CI: 0.651-0.683), respectively.
UNASSIGNED: LODDS displayed a better predictive capacity in the OS and CSS than LNR and pN stage, indicating that LODDS may be effective to predict the prognosis of colorectal SRCC in the clinic.