化学抗性以及由此产生的治疗失败在临床癌症治疗中是相当具有挑战性的。对化学抗性获得中的遗传变异的理解鼓励了使用基因调节方法来恢复抗癌药物的功效。许多智能纳米粒子被设计和优化以介导核酸和抗癌药物之间的组合治疗。这篇综述旨在定义这种共负载纳米载体的合理设计,目的是在各种细胞水平上逆转化学抗性,以改善抗癌治疗的治疗效果。通过治疗加载的原则,物理化学特性调整,和不同的纳米载体修饰,还研究了联合药物对化学敏感性恢复的有效性。到目前为止,这些新兴的纳米载体处于发展状态,但有望带来出色的成果。
Chemoresistance and hence the consequent treatment failure is considerably challenging in clinical cancer therapeutics. The understanding of the genetic variations in chemoresistance acquisition encouraged the use of gene modulatory approaches to restore anti-cancer drug efficacy. Many smart nanoparticles are designed and optimized to mediate combinational therapy between nucleic acid and anti-cancer drugs. This review aims to define a rational design of such co-loaded nanocarriers with the aim of chemoresistance reversal at various cellular levels to improve the therapeutic outcome of anticancer treatment. Going through the principles of therapeutics loading, physicochemical characteristics tuning, and different nanocarrier modifications, also looking at combination effectiveness on chemosensitivity restoration. Up to now, these emerging nanocarriers are in development status but are expected to introduce outstanding outcomes.