根据法规(EC)No396/2005的第43条,欧盟委员会要求EFSA考虑新的毒理学参考值,对现有的草甲胺的最大残留水平(MRL)进行风险评估。此外,如果需要确保充分的消费者保护,应提出低于立法中目前规定的量化限额(LOQ)。EFSA执行了各种消费者暴露计算场景,根据欧盟农药残留参考实验室(EURLs)的建议,考虑可用于草酰胺现有用途的风险评估值以及降低几种植物和动物商品的LOQ。根据消费者暴露评估的结果,考虑到许可使用草胺的作物的风险评估值和剩余商品的LOQ中现有的欧盟MRL(情景1),在34种饮食中发现了长期的消费者摄入问题.确定了各种作物的急性接触问题,包括目前被授权使用草酰胺的作物:香蕉,土豆,甜瓜,黄瓜,胡萝卜,西瓜,西红柿,西葫芦,欧洲防风草,盐和茄子/茄子。在暴露计算情景3下,考虑将所有MRL降低到最低分析可实现的定量极限,EFSA得出的结论是,仍然不能排除长期的消费者接触问题。同样,对16种商品确定了消费者对急性接触的担忧,包括已知授权用途的作物:土豆,甜瓜,西瓜和西红柿,即使对于这些作物,也考虑了EURL提出的较低LOQ。EFSA不可能对当前阶段的计算暴露进行进一步改进,但是EFSA确定了一系列商品,这些商品的LOQ低于常规可实现的水平,有望显着降低消费者的风险敞口,并且需要进行风险管理决策。
In accordance with Article 43 of Regulation (EC) No 396/2005, the European Commission requested EFSA to perform a risk assessment of the existing maximum residues levels (MRLs) for
oxamyl considering the new toxicological reference values. Additionally, if needed to ensure adequate consumer protection, lower limits of quantification (LOQs) than those currently established in the legislation should be proposed. EFSA performed various consumer exposure calculation scenarios, considering the risk assessment values as available for the existing uses of
oxamyl and the lowering of LOQs for several plant and animal commodities as suggested by the European Union Reference Laboratories for Pesticide Residues (EURLs). Based on the results of the consumer exposure assessment calculated considering the risk assessment values for crops with authorised
oxamyl uses and the existing EU MRLs at the LOQ for remaining commodities (scenario 1), chronic consumer intake concerns were identified for 34 diets. Acute exposure concerns were identified for a wide range of crops, including crops with currently authorised
oxamyl uses: bananas, potatoes, melons, cucumbers, carrots, watermelons, tomatoes, courgettes, parsnips, salsifies and aubergines/eggplants. Under exposure calculation scenario 3, which considered lowering of all MRLs to the lowest analytically achievable limits of quantification, EFSA concludes that chronic consumer exposure concerns can still not be excluded. Similarly, acute consumer exposure concerns were identified for 16 commodities, including crops with known authorised uses: potatoes, melons, watermelons and tomatoes, even though for these crops a lower LOQ as proposed by the EURLs were considered. Further refinements of the calculated exposure at the current stage were not possible by EFSA, but EFSA identified a list of commodities for which a lower LOQ than routinely achievable is expected to significantly reduce the consumer exposure and for which a risk management decision is required.