发现成骨细胞分泌激素,对代谢有内分泌作用,骨钙蛋白(osteocalcin,OC)是骨中含量最丰富的非胶原蛋白。我们研究了成骨不全症(OI)儿童的血清OC水平与糖脂代谢和肌肉功能之间的关系。
这项单中心研究共纳入225名OI儿童和80名年龄和性别相匹配的健康对照。血清空腹血糖(FBG)水平,甘油三酯(TG),总胆固醇(TC),低密度和高密度脂蛋白胆固醇(LDL-C,HDL-C)通过自动分析仪测量。使用自动电化学发光系统测量空腹胰岛素(FINS)的血清水平。通过酶联免疫吸附法测定血清OC和羧化骨钙蛋白(ucOC)水平。测量握力和定时启动(TUG)测试。使用双能X射线吸收法测量骨矿物质密度(BMD)和身体成分。
OI患者的体重指数(BMI)明显较高,FBG,和HOMA-IR,但HDL-C水平较低,握力、TUG均低于对照组(均P<0.05)。血清OC,ucOC水平,OIIII型患者的ucOC/OC明显低于OI型和IV型患者。血清OC水平,ucOC,UCOC/OC与BMI呈负相关,FBG,胰岛素水平,HOMA-IR(均P<0.05)。ucOC/OC比值与握力呈正相关(r=0.512,P=0.036),整个身体和四肢的瘦质量百分比(%LM),与全身脂肪质量百分比(%FM)呈负相关,%FM和躯干脂肪质量指数(FMI)(均P<0.05)。
肥胖,糖脂代谢异常,握力降低在OI儿童中很常见。循环骨钙蛋白和ucOC可能在调节糖代谢中起重要作用,以及OI儿童的肌肉功能。
UNASSIGNED: Osteoblasts are discovered to secrete hormones with endocrine effects on metabolism, and osteocalcin (OC) is the most abundant non-collagenous protein in bone. We investigate the relationship between serum OC levels and glycolipid metabolism and muscle function in children with osteogenesis imperfecta (OI).
UNASSIGNED: A total of 225 children with OI and 80 healthy controls matched in age and gender were included in this single center study. Serum levels of fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C) were measured by automated analyzers. Serum levels of fasting insulin (FINS) were measured using an automated electrochemiluminescence system. Serum levels of OC and undercarboxylated osteocalcin (ucOC) were measured by enzyme-linked immunosorbent assay. Grip strength and timed-up-and-go (TUG) test were measured. Bone mineral density (BMD) and body composition were measured using dual-energy X-ray absorptiometry.
UNASSIGNED: OI patients had significantly higher body mass index (BMI), FBG, and HOMA-IR, but lower HDL-C levels, lower grip strength and longer TUG than control group (all P<0.05). Serum OC, ucOC levels, and ucOC/OC in OI type III patients were significantly lower than those in OI patients with type I and IV. Serum levels of OC, ucOC, and ucOC/OC were negatively correlated to BMI, FBG, insulin levels, and HOMA-IR (all P<0.05). The ratio of ucOC/OC was positively correlated to grip strength (r=0.512, P=0.036), lean mass percentage (%LM) of the total body and limbs, and negatively correlated to fat mass percentage (%FM) of the total body, %FM and fat mass index (FMI) of the trunk (all P<0.05).
UNASSIGNED: Obesity, glucolipid metabolic abnormalities, and reduced grip strength were common in children with OI. Circulating osteocalcin and ucOC may play an important role in the regulation of glucose metabolism, as well as the muscle function of children with OI.