局部药物递送由于其非侵入性和直接应用于目标部位而在皮肤病学治疗中具有巨大的意义。有机凝胶,一类有前途的局部给药系统,在提高药物递送效率方面获得了大量关注。本文旨在探讨有机凝胶的优点,包括增强药物溶解度,控释,改善皮肤渗透,非油腻配方,和易于应用。讨论了有机凝胶渗透到皮肤中的机理,连同制定策略,其中包括胶凝剂的选择,共胶凝剂,和添加剂,同时考虑温度和pH对凝胶形成的影响。各种类型的有机凝胶剂和有机凝胶及其性质,如粘弹性,非双折射,热稳定性,和光学清晰度,被呈现。此外,有机凝胶在靶向皮肤癌中的生物医学应用,抗炎药物递送,和抗真菌药物递送进行了讨论。特征参数,生物相容性,安全考虑,以及优化皮肤渗透的未来方向,确保长期稳定,应对监管挑战,并对潜在的联合疗法进行彻底检查。总的来说,这篇综述强调了有机凝胶在重新定义局部药物递送方面的巨大潜力及其对皮肤病治疗领域的重大影响,从而为该领域令人兴奋的前景铺平了道路。
Topical drug delivery holds immense significance in dermatological treatments due to its non-invasive nature and direct application to the target site.
Organogels, a promising class of topical drug delivery systems, have acquired substantial attention for enhancing drug delivery efficiency. This review article aims to explore the advantages of
organogels, including enhanced drug solubility, controlled release, improved skin penetration, non-greasy formulations, and ease of application. The mechanism of organogel permeation into the skin is discussed, along with formulation strategies, which encompass the selection of gelling agents, cogelling agents, and additives while considering the influence of temperature and pH on gel formation. Various types of organogelators and
organogels and their properties, such as viscoelasticity, non-birefringence, thermal stability, and optical clarity, are presented. Moreover, the biomedical applications of
organogels in targeting skin cancer, anti-inflammatory drug delivery, and antifungal drug delivery are discussed. Characterization parameters, biocompatibility, safety considerations, and future directions in optimizing skin permeation, ensuring long-term stability, addressing regulatory challenges, and exploring potential combination therapies are thoroughly examined. Overall, this review highlights the immense potential of
organogels in redefining topical drug delivery and their significant impact on the field of dermatological treatments, thus paving the way for exciting prospects in the domain.