未经证实:肺癌中肺大细胞神经内分泌癌(LCNEC)的发病率较低,但恶性程度高,预后差。我们用了监控,流行病学,和最终结果(SEER)数据库,以确定LCNEC器官转移的人群分布,进行生存分析,判断预后因素,为后续诊断和治疗提供指导。
UNASSIGNED:通过登录SEER数据库,检索肺LCNEC的数据并选择目标人群.根据是否存在器官转移(骨,大脑,肝脏,和肺),我们将目标人群分为无器官转移组(n=1,202)和器官转移组(n=870)。通过分析患者的临床病理资料,运用生存功能,获得相应的中位生存时间,并对各组的影响因素进行分析。然后,对显著影响因素进行多因素Cox回归分析,筛选出独立影响因素。
UNASSIGNED:在整个样本组中,多因素Cox回归分析显示,性别,年龄,主要部位手术,骨转移,脑转移瘤,肝转移,放射治疗,化疗是影响预后的独立因素。骨转移组1年生存率为13.8%,脑转移组19.1%,肝转移组13.8%,肺内转移组为20.3%。在器官转移组中,多因素Cox回归分析显示,性别,化疗,放疗序列与手术,主要部位手术,肝转移,诊断年龄是影响预后的独立因素。
未经评估:在LCNEC的整体样本中,骨转移,脑转移瘤,和肝转移都减少了总生存时间,而肺内转移对总生存期的影响无统计学意义。性,化疗,放疗序列与手术,主要部位手术,肝转移,年龄是影响LCNEC器官转移组预后的独立因素。女人,化疗,放疗顺序和手术是有利因素,当年老时,肝转移,男性是不利因素。
UNASSIGNED: The incidence rate of lung large cell neuroendocrine carcinoma (LCNEC) in lung cancer is low, but the malignancy is high and the prognosis is poor. We used the Surveillance, Epidemiology, and End Results (SEER) database to determine the population distribution of organ metastasis in LCNEC, conduct survival analysis, judge prognostic factors, and provide direction for follow-up diagnosis and treatment.
UNASSIGNED: By logging into the SEER database, the data of lung LCNEC were retrieved and the target population was selected. According to the presence or absence of organ metastasis (bone, brain, liver, and lung), we divided the target population into the no organ metastasis group (n = 1,202) and the organ metastasis group (n = 870). By analyzing the clinicopathological data of patients and using the survival function, the corresponding median survival time was obtained, and the influencing factors of each group were analyzed. Then, the significant influencing factors were analyzed by multivariate Cox regression analysis to screen out the independent influencing factors.
UNASSIGNED: In the overall sample group, multivariate Cox regression analysis showed that sex, age, primary site surgery, bone metastasis, brain metastasis, liver metastasis, radiotherapy, and chemotherapy were independent prognostic factors. The 1-year survival rate was 13.8% in the bone metastasis group, 19.1% in the brain metastasis group, 13.8% in the liver metastasis group, and 20.3% in the intrapulmonary metastasis group. In the organ metastasis group, multivariate Cox regression analysis showed that sex, chemotherapy, radiotherapy sequence with surgery, primary site surgery, liver metastasis, and age at diagnosis were independent factors affecting the prognosis.
UNASSIGNED: In the overall sample of LCNEC, bone metastasis, brain metastasis, and liver metastasis all reduced the overall survival time, while the effect of intrapulmonary metastasis on the overall survival time was not statistically significant. Sex, chemotherapy, radiotherapy sequence with surgery, primary site surgery, liver metastasis, and age were independent factors affecting the prognosis of the LCNEC organ metastasis group. Women, chemotherapy, and radiotherapy sequence with surgery were favorable factors, while old age, liver metastasis, and male were unfavorable factors.