目的:本横断面研究的目的是评估有双相情感障碍病史的患者的牙周状况以及牙周炎与口腔健康相关生活质量(OHRQoL)的关系。
方法:共招募了160名参与者,分为四组进行研究:40名患者出现正常发作,40名抑郁症患者,40名躁狂发作患者和40名全身健康个体。记录临床牙周参数。口腔健康影响概况(OHIP-14)用于测量口腔健康对生活质量的影响。
结果:与对照组相比,双相情感障碍组表现出更高的临床参数(p<0.05)。OHIP-14总分(β=3.32,95%置信区间[CI]:0.08-6.56,p=0.044),功能受限(β=.89,95%CI:0.27-1.49,p=.005)和身体疼痛(β=.64,95%CI:0.01-1.27,p=.046)与双相抑郁发作相关。心理不适与广泛性牙周炎的存在有关(β=.76,95%CI:0.01-1.51,p=.047),而心理残疾与III-IV期(β=.83,95%CI:0.07-1.59,p=.033)和广泛性(β=.75,95%CI:0.07-1.42,p=.029)牙周炎的存在有关。
结论:根据这项研究,双相情感障碍发作史(暴露)可能与牙周炎患病率和严重程度增加以及相关报告的OHRQoL影响(结局)相关.双相抑郁发作对OHRQoL的影响高于其他双相发作。
The aim of the present cross-sectional study was to evaluate periodontal conditions and the association of periodontitis with oral-health-related quality of life (OHRQoL) in patients with a history of bipolar disorder.
A total of 160 participants were recruited in four groups for the study: 40 patients with euthymic episodes, 40 patients with depression, 40 patients with manic episodes and 40 systemically healthy individuals. Clinical periodontal parameters were recorded. Oral Health Impact Profile (OHIP-14) was used to measure the impact of oral health on the quality of life.
Bipolar disorder groups exhibited generally higher clinical parameters compared with the control group (p < .05). OHIP-14 total score (β = 3.32, 95% confidence interval [CI]: 0.08-6.56, p = .044), functional limitation (β = .89, 95% CI: 0.27-1.49, p = .005) and physical pain (β = .64, 95% CI: 0.01-1.27, p = .046) were associated with bipolar depression episodes. Psychological discomfort was associated with the presence of generalized periodontitis (β = .76, 95% CI: 0.01-1.51, p = .047) and psychological disability was associated with the presence of stage III-IV (β = .83, 95% CI: 0.07-1.59, p = .033) and generalized (β = .75, 95% CI: 0.07-1.42, p = .029) periodontitis.
According to this study, a history of bipolar disorder episodes (exposure) may be associated with increased prevalence and severity of periodontitis and related reported OHRQoL impacts (outcomes). Bipolar depression episodes had a higher impact on OHRQoL than other bipolar episodes.