■化疗引起的粘膜炎是由于抗癌治疗而在口腔粘膜中发展的炎症。粘膜炎有负面后果,可能导致儿科患者的痛苦,导致费用增加,生活质量下降,癌症治疗的障碍,存活率下降。然而,尽管方法众多,尽管缺乏高水平的证据研究,但建议在儿科人群中实施口腔护理方案,特别是关于应施用哪些适当的口腔护理剂。
■本系统综述旨在确定口腔护理干预在小儿癌症患者粘膜炎管理中的作用。
■研究发表于2014年至2023年之间,来自五个数据库:PubMed,Embase,Medline,ScienceDirect,还有Scopus.他们使用搜索策略来确定相关研究,这些研究确定了口腔护理干预措施来管理癌症儿童的粘膜炎。这项研究使用JoannaBriggs研究所(JBI)的关键评估工具来评估研究的质量,并遵循推荐的报告项目进行系统评价和荟萃分析(PRISMA)指南。
■8项研究符合纳入标准,包括七个随机对照试验和一个准实验研究。涉及刷牙的口腔护理干预措施,漱口水,和嘴唇护理全部或部分进行。口腔护理的频率从每天两到六次不等,干预时间为5天至6周。使用蜂蜜的口腔护理干预措施,橄榄油,芦荟,安迪罗巴,和唾液酶牙膏有利于降低粘膜炎的严重程度,减轻疼痛,减少粘膜炎的持续时间,减少镇痛药的使用,但并不能显著提高孩子的生活质量。然而,Caphosol漱口水并未显着减轻粘膜炎。
■我们的研究强调,综合使用有效药物进行口腔护理干预,包括蜂蜜,橄榄油,芦荟,安迪罗巴,还有唾液酵素牙膏,对于治疗儿童化疗引起的粘膜炎至关重要。
■PROSPERO注册号为CRD42023456278。
UNASSIGNED: Chemotherapy-induced mucositis is inflammation that develops in the oral mucosal due to anticancer treatment. Mucositis has negative consequences that may lead to distress in pediatric patients, resulting in escalated expenses, diminished quality of life, hindrance in cancer therapy, and decreased survival rates. However, despite the numerous methods, oral care protocols are suggested for implementation in the pediatric population despite a lack of high-level evidence studies, particularly regarding which appropriate oral care agents should be administered.
UNASSIGNED: This systematic review aimed to identify the effect of oral care intervention in mucositis management among pediatric cancer patients.
UNASSIGNED: Studies were published between 2014 and 2023 from five databases: PubMed, Embase, Medline, ScienceDirect, and Scopus. They were identified using a search strategy to identify relevant studies that identify oral care interventions for managing mucositis in children with cancer. This study used the Joanna Briggs Institute (JBI) critical appraisal tools to assess the quality of the studies and followed the recommended reporting items for systematic reviews and meta-analyses (PRISMA) guidelines.
UNASSIGNED: Eight studies met the inclusion criteria, including seven RCTs and one quasi-experimental study. Oral care interventions involving tooth brushing, mouthwash, and lip care are performed entirely or partially. The frequency of oral care ranges from two to six times daily, and the duration of intervention is from 5 days to six weeks. Oral care interventions using honey, olive oil, Aloe Vera, Andiroba, and salivary enzyme toothpaste are beneficial to lower the severity of mucositis, reduce pain, minimize mucositis duration, and reduce the use of analgesics, but not significantly improve the child\'s quality of life. However, Caphosol mouthwash did not significantly reduce mucositis.
UNASSIGNED: Our study highlights that oral care intervention using effective agents integratively, including honey, olive oil, Aloe vera, Andiroba, and salivary enzyme toothpaste, is essential to manage chemotherapy-induced mucositis among children.
UNASSIGNED: PROSPERO registration number was CRD42023456278.