目的:我们的目的是报告8例接受23号平面部玻璃体切除术(PPV)治疗的视盘凹坑黄斑病变(ODP-M)患者的光学相干断层扫描血管造影(OCTA)结果。
方法:我们检查了8名患者的16只眼——8只ODP-M眼和8只健康的同伴眼。眼底彩色摄影,眼底自发荧光,荧光素眼底血管造影,光学相干断层扫描(OCT),进行了OCTA。血管密度,脉络膜毛细血管血流(CCBF),使用OCTA分析和中央凹无血管区(FAZ)。此外,评估最佳矫正视力(BCVA)与黄斑OCTA参数之间的相关性.
结果:与健康的眼睛相比,术前患有ODP-M的眼睛发现BCVA降低,浅表毛细血管丛(SCP)血管密度(即total,中央凹,侧腹,和中央凹),深毛细血管丛(DCP)血管密度(即total,侧腹,和中央凹),和CCBF,但显著增加FAZ(p<0.05)。当ODP-M的眼睛在手术后12个月进行术前和术后分析时,BCVA,SCP血管密度(即,中央凹),CCBF显著增加,FAZ显著下降(p<0.05)。当ODP-M的眼睛在术后12个月与健康的其他眼睛比较时,BCVA,SCP,DCP血管密度参数增加,随着CCBF,ODP-M的FAZ减少了,虽然没有达到健康同伴眼睛的水平(p<0.05)。此外,术后BCVA和SCP总血管密度呈正相关(p<0.05)。
结论:术后第12个月,ODP-M患者的BCVA和黄斑OCTA参数改善。然而,手术眼睛的BCVA和OCTA没有达到健康眼睛的水平,可能是由于脉络膜血流(CBF)恢复受损和存在较大的FAZ。总之,OCTA似乎可用于评估围手术期微血管的定性和定量变化。
OBJECTIVE: we aimed to report on the optical coherence tomography angiography (OCTA) outcomes of eight patients with optic disc pit maculopathy (ODP-M) who were treated with 23-gauge pars plana vitrectomy (PPV).
METHODS: We examined sixteen eyes of eight patients-eight eyes with ODP-M and eight healthy fellow eyes. Fundus color photography, fundus autofluorescence, fundus fluorescein angiography, optical coherence tomography (OCT), and OCTA were performed. The vascular density, choriocapillaris blood flow (CCBF), and foveal avascular zone (FAZ) were analyzed using OCTA. Moreover, the correlation between the best-corrected visual acuity (BCVA) and macular OCTA parameters was assessed.
RESULTS: Compared with the healthy fellow eyes, the eyes with ODP-M preoperatively were found to have decreased BCVA, superficial capillary plexus (SCP) vascular density (i.e., total, foveal, parafoveal, and perifoveal), deep capillary plexus (DCP) vascular density (i.e., total, parafoveal, and perifoveal), and CCBF but a significantly increased FAZ (p < 0.05). When the eyes with ODP-M were analyzed pre- and postoperatively at month 12 after surgery, the BCVA, SCP vascular density (i.e., perifoveal), and CCBF had significantly increased, and the FAZ had significantly decreased (p < 0.05). When the eyes with ODP-M were compared with the healthy fellow eyes postoperatively at month 12, the BCVA, SCP, and DCP vascular density parameters had increased, along with CCBF, and the FAZ had decreased in eyes with ODP-M, though not to the levels of the healthy fellow eyes (p < 0.05). Moreover, a positive correlation was found between the postoperative BCVA and SCP total vascular density (p < 0.05).
CONCLUSIONS: The BCVA and macular OCTA parameters improved in eyes with ODP-M at month 12 following surgery. However, the BCVA and OCTA of the eyes operated on did not reach the levels of the healthy fellow eyes, possibly due to impaired choroidal blood flow (CBF) recovery and the presence of a larger FAZ. In summary, OCTA seems to be useful for assessing qualitative and quantitative perioperative microvascular changes.