毛滴虫(TTM),祛除障碍,甲癣,和onychotillomania被归类为身体集中的重复行为(BFRB)障碍,对皮肤造成伤害,头发,和/或具有临床重大社会心理后果的指甲。目前,这些强迫性没有标准化的治疗方法,自我诱发的疾病。使用精神药物治疗这些疾病的研究(即,选择性5-羟色胺再摄取抑制剂,三环抗抑郁药,抗惊厥药)已显示出可变的功效。最近,对于用于治疗BFRB的N-乙酰半胱氨酸(NAC)存在日益增长的兴趣。NAC是一种谷氨酸调节剂,已显示出成功减少BFRB障碍中的强迫行为的希望。本文提供了有关NAC在TTM中使用的最新文献综述,祛除障碍,甲癣,和onychotillomania。
在PubMed/MEDLINE数据库中搜索了相关文章。
24项临床试验,回顾性队列研究,和病例报告评估NAC在TTM中的疗效,祛除障碍,包括甲癣。在我们的搜索中没有发现有关onychotillomania的研究。
虽然NAC已被证明可以成功治疗BFRB疾病,数据来自很少的临床试验和病例报告,评估少数患者。需要更长持续时间的更大规模的研究来充分确定NAC在这些疾病中的功效。
Trichotillomania (TTM), excoriation disorder, onychophagia, and
onychotillomania are categorized as body focused repetitive behavior (BFRB) disorders, causing damage to the skin, hair, and/or nails with clinically significant psychosocial consequences. Currently, there are no standardized treatments for these compulsive, self-induced disorders. Studies on treatment of these disorders using psychotropic drugs (i.e., selective serotonin reuptake inhibitors, tricyclic antidepressants, anticonvulsants) have shown variable efficacy. Recently, there is a growing interest in N-acetylcysteine (NAC) for treating BFRBs. NAC is a glutamate modulator that has shown promise in successfully reducing the compulsive behaviors in BFRB disorders. This article provides an updated review of the literature on the use of NAC in TTM, excoriation disorder, onychophagia, and
onychotillomania.
Relevant articles were searched in the PubMed/MEDLINE database.
Twenty-four clinical trials, retrospective cohort studies, and case reports assessing the efficacy of NAC in TTM, excoriation disorder, and onychophagia were included. No studies for
onychotillomania were found in our search.
Although NAC has proven successful for treatment of BFRB disorders, data is derived from few clinical trials and case reports assessing small numbers of patients. Larger studies with longer durations are needed to fully establish the efficacy of NAC in these disorders.