目的:这项回顾性研究旨在描述脐部的解剖参数,并分析其与解剖,遗传,或综合征畸形。
方法:从两个大学中心的数字记录中选择案例,经认证的区域登记处和个人记录。1998年至2018年患有脐膨出和活产(LB)的患者,包括因胎儿异常(TOPFA)和胎儿死亡(FD)而终止妊娠。排除在瑞士西部以外出生和/或患有上或下体腔切开术的病例。
结果:我们分析了162例,分布如下:57(35%)LB,91(56%)TOPFA和14(9%)FD。TOPFA在非孤立性脐膨出的病例中明显更常见,即,与相关的主要畸形(尤其是心血管和泌尿生殖系统),遗传/染色体异常,或综合症。对于LB,相关的解剖畸形,遗传或染色体异常与脐膨出或肝脏受累的大小无显著相关.
结论:在有严重畸形的胎儿中,导致TOPFA的病例比例较高,遗传或染色体异常。尽管这个群体规模很大,与以前的出版物相反,脐膨出和/或肝脏受累的大小不能得出相关畸形的存在或数量的结论,遗传或染色体异常。
OBJECTIVE: This retrospective study aims to describe anatomical parameters of omphaloceles and to analyze their association with anatomical, genetic, or syndromic malformations.
METHODS: Cases were selected from digital records of two university centers, a certified regional registry and personal records. Patients from 1998 to 2018 with
omphalocele and live birth (LB), termination of pregnancy due to fetal anomaly (TOPFA) and fetal death (FD) were included. Cases born outside Western Switzerland and/or with upper or lower coelosomy were excluded.
RESULTS: We analyzed 162 cases with the following distribution: 57 (35%) LB, 91 (56%) TOPFA and 14 (9%) FD. TOPFA was significantly more frequently performed in cases with non-isolated
omphalocele, i.e., omphaloceles with associated major malformations (especially cardiovascular and genitourinary), genetic/chromosomal anomalies, or syndromes. For LB, associated anatomical malformations, genetic or chromosomal anomalies were not significantly associated with the size of the
omphalocele or the liver involvement.
CONCLUSIONS: The proportion of cases resulting in TOPFA was higher among fetuses with major malformations, genetic or chromosomal anomalies. Despite the large size of this cohort, and in contrary to previous publications, the size of the
omphalocele and/or liver involvement does not allow for conclusions regarding the presence or number of associated malformations, genetic or chromosomal anomalies.