牙源性肿瘤(OTs)是在颌骨中发展的独特条件,表现出不同的组织病理学特征和不同的临床行为。不幸的是,沙特阿拉伯关于这个问题的文献仍然很少,表明迫切需要更全面的频率数据,人口统计,治疗方式,以及OTS的结果。
目的:该研究旨在评估频率,人口特征,治疗,以及三个三级医疗中心的OTs结果。
方法:在阿卜杜勒阿齐兹国王医疗城(KAMC)中发现了OT病例,法哈德国王医疗城(KFMC),2010年1月至2021年12月,苏丹王子军事医学城(PSMMC)。
结果:在三家三级医院的解剖病理实验室中发现了92例OT病例。KFMC贡献了最高的病例数(43.5%),其次是KAMC(30.4%)和PSMMC(26.1%)。OT患者的中位年龄为29岁(范围:5-83),男性占患者的一半以上(56.5%)。下颌骨是OT发生的最常见部位(72.5%),成釉细胞瘤是主要的OT(63.0%),其次是牙瘤(19.5%)。在治疗方式中,骨切除最多(51.0%),其次是眼球摘除(25.6%)。值得注意的是,有随访数据的OT病例中,有11.5%出现复发,成釉细胞瘤占8例复发病例。
结论:尽管OTs在颌骨中相对常见,它们在解剖病理学实验室和普通人群中很少见。这项研究为流行病学特征提供了宝贵的见解,治疗趋势,沙特阿拉伯的OTs复发率。
Odontogenic tumors (OTs) are distinct conditions that develop in the jawbones, exhibiting diverse histopathological features and variable clinical behaviors. Unfortunately, the literature on this subject in Saudi Arabia remains sparse, indicating a pressing need for more comprehensive data concerning the frequency, demographics, treatment modalities, and outcomes of OTs.
OBJECTIVE: The study aims to evaluate the frequency, demographic features, treatment, and outcomes of OTs across three tertiary medical centers.
METHODS: OT cases were identified in King Abdulaziz Medical City (KAMC), King Fahad Medical City (KFMC), and Prince Sultan Military Medical City (PSMMC) from January 2010 to December 2021.
RESULTS: Ninety-two OT cases were identified from the anatomical pathology laboratories of three tertiary hospitals. KFMC contributed the highest number of cases (43.5%), followed by KAMC (30.4%) and PSMMC (26.1%). The median age of OT patients was 29 years (range: 5-83), with males representing more than half of the patients (56.5%). The mandible was the most frequent site of OT occurrence (72.5%), with ameloblastoma being the predominant OT (63.0%), followed by
odontoma (19.5%). Among the treatment modalities, bone resection was employed the most (51.0%), followed by enucleation (25.6%). Notably, 11.5% of OT cases with available follow-up data exhibited recurrence, with ameloblastoma accounting for eight recurrent cases.
CONCLUSIONS: Although OTs are relatively common in the jaws, they are rare in anatomical pathology laboratories and the general population. This study contributes valuable insights into the epidemiology characteristics, treatment trends, and recurrence rates of OTs in Saudi Arabia.