目的:牙源性感染的患病率仍然是世界上最高的之一。如果未经治疗,牙源性感染可以突破限制,传播到其他器官或空间,并导致高死亡率。然而,在临床实践中,仍然很难快速靶向有限或播散性感染。尚未详细描述散布的牙源性感染的类型和负责的细菌。
方法:搜索数据库(例如,PubMed,MEDLINE,WebofScience,Embase)用于2018.1至2022.9发布的报告。使用搜索策略:(\"牙源性感染\"或\"牙髓炎\"或\"根尖周病变\"或\"牙周疾病\")和(\"播散性感染\"或\"并发症\")。
结果:十四种不同类型的播散性牙源性感染,其中大多数是多微生物感染,可以直接或通过血源性扩散通过身体传播。多种微生物感染在感染的传播中可以更具侵袭性。继发感染通常与诸如梭杆菌属的细菌有关。,链球菌属。,肽链球菌属。,普雷沃氏菌属。,和葡萄球菌属。基于从播散性感染中分离的微生物,具有广谱活性的抗生素是作为一线抗微生物剂的基础。
结论:这篇综述阐述了流行病学,微生物,危险因素,和传播路线,并提供基于证据的诊断意见,多学科管理,和预防牙源性感染的牙医和临床医生。
OBJECTIVE: The prevalence of odontogenic infections remains one of the highest in the world. If untreated, odontogenic infections can break through the limitation, disseminate to other organs or spaces, and cause high mortality rates. However, it is still difficult to rapidly target limited or disseminated infections in clinical practice. The type of disseminated odontogenic infections and the responsible bacteria have not been described in detail.
METHODS: Search databases (e.g., PubMed, MEDLINE, Web of Science, Embase) for reports published from 2018.1 to 2022.9. Use search strategies: (\"odontogenic infections\" OR \"pulpitis\" OR \"periapical lesions\" OR \"periodontal diseases\") AND (\"disseminated infections\" OR \"complication\").
RESULTS: Fourteen different types of disseminated odontogenic infections, most of which are polymicrobial infections, can spread through the body either direct or through hematogenous diffusion. Multiple microbial infections can be more invasive in the transmission of infection. Secondary infections are commonly associated with bacteria like Fusobacterium spp., Streptococcus spp., Peptostreptococcus spp., Prevotella spp., and Staphylococcus spp. Antibiotics with broad-spectrum activity are fundamental as first-line antimicrobial agents based on the microorganisms isolated from disseminated infections.
CONCLUSIONS: This review elaborates on the epidemiology, microorganisms, risk factors, and dissemination routes, and provides evidence-based opinions on the diagnosis, multidisciplinary management, and prevention of odontogenic infections for dentists and clinicians.