■要比较血压(BP),眼内压(IOP),眼动脉血流(OAF)速度,视网膜神经纤维层(RNFL)厚度,和视野在新诊断的高血压(HT)患者(治疗前),慢性HT(抗高血压药物治疗>5年)和常规。
■预期,印度三级护理中心的横断面研究。三组各45例患者:第1组——早期HT,第2组-慢性HT,和第3组——正规化,接受了BP的评估,戈德曼压平眼压法(GAT),通过经颅多普勒(TCD)的OAF速度,通过光谱域光学相干断层扫描(SD-OCT)进行RNFL分析,和视野。
■早期HT>慢性HT>正常血压最高(p<0.001)。早期HT的IOP,慢性HT,正常值为15.87±2.19mmHg,13.47±1.92mmHg,15.67±SD1.75mmHg(p<0.001)。OAF速度[峰值收缩期速度(PSV),舒张末期流速(EDV)以cm/sec为单位]在慢性HT(30.80±7.05,8.58±1.58)<早期HT(35.47±5.34,10.02±1.74)<正常(36.29±4.43,10.44±2.29)中最低,(p<0.001)。慢性HT的平均RNFL厚度显著降低(p=0.022)。PSV,EDV,和MFV与IOP(r=0.247,p=0.004;r=0.206,p=0.016;r=0.266,p=0.002)和平均RNFL厚度(r=0.309,p=<0.001;r=0.277,p=0.001;r=0.341,p<0.001)显着相关。
■慢性HT患者表现出最低的球后血流,IOP和较低的RNFL测量。较低的眼部灌注可能与较低的IOP相关,并且可能是独立于IOP的终末器官损伤(RNFL)的危险因素。
To compare blood pressure (BP), intraocular pressure (IOP), ophthalmic artery flow (OAF) velocity, retinal nerve fiber layer (RNFL) thickness, and visual fields in newly diagnosed hypertension (HT) patients (before treatment), chronic HT (on antihypertensive medications >5 years) and normotensives.
A prospective, cross-sectional study at a tertiary care centre in India. Three groups of 45 patients each: group 1 - early HT, group 2 - chronic HT, and Group 3 - normotensives, underwent evaluation of BP, IOP by Goldmann applanation tonometry (GAT), OAF velocity by transcranial doppler (TCD), RNFL analysis by spectral-domain optical coherence tomography (SD-OCT), and visual fields.
The BP was highest in early HT > chronic HT > normotensives (p < 0.001). The IOP of early HT, chronic HT, and normotensives were 15.87 ± 2.19 mmHg, 13.47 ± 1.92 mmHg, and 15.67 ± SD 1.75 mmHg (p < 0.001). The OAF velocity [peak systolic velocity (PSV), end-diastolic velocity (EDV) in cm/sec] was lowest in chronic HT (30.80 ± 7.05, 8.58 ± 1.58) < early HT (35.47 ± 5.34, 10.02 ± 1.74) < normotensives (36.29 ± 4.43, 10.44 ± 2.29), (p < 0.001). The average RNFL thickness was significantly lower in chronic HT (p = 0.022). The PSV, EDV, and MFV showed significant correlation with IOP (r = 0.247, p = 0.004; r = 0.206, p = 0.016; r = 0.266, p = 0.002) and average RNFL thickness (r = 0.309, p= <0.001; r = 0.277, p = 0.001; r = 0.341, p < 0.001).
Patients with chronic HT demonstrated the lowest retrobulbar flows, IOP and lower RNFL measurements. Lower ocular perfusion may be associated with lower IOP and may be a risk factor for end-organ damage (RNFL) independent of IOP.