在过去的十年里,致力于揭示紧密连接蛋白在与缺血性卒中相关的血脑屏障(BBB)损伤中的复杂作用的研究激增.这种文献计量学分析探索了occludin研究的广阔景观,一种关键的紧密连接蛋白,在2000-2023年期间,阐明了全球科学贡献,合作,以及中风发病机制这一关键领域的新兴趋势。中国和美国成为重要的贡献者,强调了它们在促进我们对紧密连接蛋白的理解方面的重要性。Occludin,被认为是调节血脑屏障完整性的关键,被证明是一个关键的角色,影响延伸到缺血性卒中出血性转化的诊断。这项研究将occludin确定为潜在的生物标志物,为早期诊断提供希望,并为新的诊断策略铺平道路。分析强调了对紧密连接蛋白进行更全面探索的必要性,包括occludin和claudin-5,特别是在急性脑缺血的情况下。哈萨克斯坦独特的医疗保健景观增加了在该地区进行进一步科学研究的紧迫性。强调需要有针对性的调查,以应对具体的区域挑战。这个全面的概述不仅描述了occludin研究的当前状态,而且为未来的研究指明了方向。确定的知识差距和新兴趋势为研究人员和政策制定者提供了路线图,对科学话语和临床实践都有影响。往前走,对紧密连接蛋白有更深入的了解,从这项研究中收集到的见解,具有形成有针对性的治疗干预和诊断策略的潜力,最终有助于全球卒中护理的进步。
Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood-brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of
occludin research, a key tight junction protein, during the years 2000-2023, shedding light on the global scientific contributions, collaborations, and emerging trends in this critical area of stroke pathogenesis. China and the United States emerge as significant contributors, underscoring their prominence in advancing our understanding of tight junction proteins.
Occludin, identified as a linchpin in regulating BBB integrity, proves to be a pivotal player, with implications extending to the diagnosis of hemorrhagic transformation in ischemic stroke. This study identifies
occludin as a potential biomarker, offering promise for early diagnosis and paving the way for novel diagnostic strategies. The analysis highlights the necessity for a more comprehensive exploration of tight junction proteins, including
occludin and claudin-5, particularly in the context of acute cerebral ischemia. The unique healthcare landscape in Kazakhstan adds urgency to the call for further scientific research in this region, emphasizing the need for tailored investigations to address specific regional challenges. This comprehensive overview not only delineates the current state of
occludin research but also signals the direction for future investigations. The identified knowledge gaps and emerging trends provide a roadmap for researchers and policymakers alike, with implications for both scientific discourse and clinical practice. Moving forward, a deeper understanding of tight junction proteins, informed by the insights gleaned from this study, holds the potential to shape targeted therapeutic interventions and diagnostic strategies, ultimately contributing to advancements in global stroke care.