背景:接受放射治疗的患者有时会在照射过程中抱怨闪光。这种光的特性的细节没有描述。
目的:评估光子和质子放射治疗过程中的闪光。
方法:对2019年1月至2020年8月在两个中心接受光子和质子治疗的所有成年患者(≥20岁)进行了一项前瞻性观察性研究,但无法沟通的患者和视觉异常的患者除外。对存在或不存在闪光进行评估,光明黑暗(7级),光强度(5级),频率,光运动,灯闪烁,和时间看到光,使用每周检查表。
结果:共检查了621例患者的650个疗程,其中416人接受了光子放射治疗,205人接受了质子束治疗。检查表显示,有88名患者(16.1%)在光子或质子放射治疗期间感觉到光。在多变量逻辑回归分析中,与闪光显著相关的因素是较高的视网膜剂量和较年轻的年龄(p<0.001).只有35/524例患者(6.7%)未照射视网膜,但是到13/33(39.4%)和41/64(64.1%),视网膜的最大等剂量线分别为10-50%和60-100%,分别。感觉到蓝色的患者数量,紫色,黄色,红色,白色和其他颜色分别为52、15、15、9、16和8(可能有多种选择)。52例患者(59%)观察到光运动。灯的位置被定义为近,远,中间有70、13和5名患者,分别。看到光的中位时间为10s。
结论:许多患者在放疗期间感觉到闪光。视网膜剂量和年龄较小与闪光频率显着相关。
BACKGROUND: Patients who receive radiation therapy sometimes complain of a light flash during irradiation. The details of the characteristics of this light have not been described.
OBJECTIVE: To evaluate light flashes during photon and proton radiotherapy.
METHODS: A prospective observational study was performed in all adult patients (≥20 years old) who received photon and proton therapy at two centers between January 2019 and August 2020, except for patients who could not communicate and those with visual abnormality. Evaluations were obtained for the presence or absence of light flashes, light darkness (7 levels), light intensity (5 levels), frequency, light movement, light flashing, and time seeing the light, using a weekly checklist.
RESULTS: A total of 650 courses were examined for 621 patients, of whom 416 received photon radiotherapy and 205 received proton beam therapy. The checklist indicated that 88 patients (16.1%) sensed light during photon or proton radiotherapy. In multivariate logistic regression analysis, the factors that were significantly associated with a light flash were a higher retina dose and younger age (p < 0.001). Light flashes were seen by only 35/524 patients (6.7%) for whom the retina was not irradiated, but by 13/33 (39.4%) and 41/64 (64.1%) with maximum isodose lines for the retina of 10-50% and 60-100%, respectively. The numbers of patients who sensed blue, purple, yellow, red, white and other colors were 52, 15, 15, 9, 16 and 8, respectively (multiple selections possible). Light movement was observed by 52 patients (59%). The location of the light was defined as near, far, and middle by 70, 13, and 5 patients, respectively. The median time the light was seen was 10 s.
CONCLUSIONS: Many patients sense light flashes during radiotherapy. The retina dose and a younger age were significantly associated with the frequency of light flashes.