目的:已经检查了一组因实体肿瘤而接受化疗(CT)的肿瘤患者的口腔问题。患者自我报告的口腔问题的发生率和严重程度已经随着他们与年龄的相互作用进行了评估,性别,肿瘤诊断和分期,mestastasis的存在,CT剂类型,和CT周期数。我们还分析了感觉异常和麻醉的存在及其与临床和治疗相关变量相关的诱发因素。
方法:要求患者填写问卷,以评估口腔和口周疼痛的发作和强度,口腔粘膜炎,唾液腺功能减退,熟食症,吞咽困难,发音困难,和自上次CT输注以来的敏感性神经病(感觉异常或感觉障碍)。我们还调查了哪些类型的药物可能被使用,以及谁推荐了它,以及患者对CT期间出现口腔问题的可能性的认识程度。
结果:我们招募了194名患者,获得了491份问卷。我们发现转移性疾病是OM(OR2.02,p=0.026)和唾液腺功能减退(OR1.66,p=0.042)的危险因素,与有丝分裂抑制剂相比,增加发生唾液腺功能减退的风险(OR2.16,p=0.013),吞咽困难(OR3.26,p=0.001),和麻醉(OR5.16,p=0.041)。年轻是大多数症状的轻微保护因素。80%的入选患者由肿瘤学家告知CT期间可能出现的口腔问题。
结论:我们的研究强调了从患者的角度收集观察数据的重要性,即在常规肿瘤学实践中出现的口腔问题。跨越一系列实体瘤和CT方案。这些发现的相关性集中在多学科团队在建议患者可能发生的口腔问题方面的关键作用。也通过推荐他们的管理。
OBJECTIVE: Oral problems in a group of oncological patients undergoing chemotherapy (CT) for solid tumors have been examined. Incidence and severity of patients\' self-reported oral problems have been evaluated along their interaction with age, gender, tumor diagnosis and stage, presence of mestastasis, CT agent type, and number of CT cycle. We also analyzed the presence of paraesthesia and anaesthesia and their predisposing factors associated with clinical and treatment-related variables.
METHODS: Patients were asked to fill in a questionnaire to evaluate the onset and the intensity of oral and perioral pain, oral mucositis, salivary gland hypofunction, dysgeusia, dysphagia, dysphonia, and sensitivity neuropathy (paraesthesia or dysaesthesia) since the last CT infusion. We also investigated which types of medications have possibly been used and who recommended it, as well as patients\' degree of awareness about the possibility of oral problems arising during CT.
RESULTS: We recruited 194 patients and obtained 491 questionnaires. We found that a metastatic disease was a risk factor for OM (OR 2.02, p = 0.026) and salivary gland hypofunction (OR 1.66, p = 0.042) and that platinum agents, compared to mitotic inhibitors, increased the risk of developing salivary gland hypofunction (OR 2.16, p = 0.013), dysphagia (OR 3.26, p = 0.001), and anaesthesia (OR 5.16, p = 0.041). Young age was a slight protective factor for most symptoms. The 80% of enrolled patients were informed by the oncologist about possible oral problems arising during CT.
CONCLUSIONS: Our study highlighted the importance of collecting observational data from the patients\' perspective on oral problems arising during the routine oncology practice, across a range of solid tumors and CT regimens. The relevance of these findings focused on the key role of the multidisciplinary team in advising the patients on the possible occurrence of oral problems, also by recommending their management.