背景:表征白内障患者的晶状体厚度(LT)对于更好地理解晶状体老化过程和设计新的人工晶状体屈光力公式很重要。本研究旨在分析常见老年性白内障形成对LT,前(ACS)和后(PCS)皮质空间,和核厚度(NT),控制性,年龄,和轴向长度。
方法:进行横断面研究。603名志愿者的连续样本(403名女性,招募200名男性),年龄59.1±18.8岁。使用标准化晶状体混浊分类系统(LOCS)-III将眼睛(随机选择的)分类为白内障组和非白内障组。此外,它们根据白内障的位置(皮质的存在或不存在,核,或后囊下白内障)。进行光学生物测量以测量LT,ACS,NT,和PCS。倾向评分用于一对一匹配参与者的性别,年龄,和轴向长度。使用学生t检验或Yuen检验对各组进行比较。
结果:四种分类将无与伦比的眼睛分为:361个白内障晶状体和242个非白内障,226皮质和377非皮质性白内障,313核白内障和290非核白内障,242包膜下白内障和361非囊膜下白内障。匹配之前,白内障的眼睛显示出明显更高的LT(4.52±0.39vs.3.94±0.46mm,p<0.001),ACS(0.75±0.20vs.0.58±0.23mm,p<0.001),NT(3.34±0.23vs.3.18±0.25mm,p<0.001)和PCS(0.42±0.19vs.0.37±0.19mm,p=0.003)。匹配的镜头,皮质,核,囊下白内障样本包括146、258、182和226只眼,分别。匹配后,在LT中没有观察到显著差异(4.34±0.37vs.4.33±0.36mm,p=0.94),ACS(0.72±0.20vs.0.76±0.19mm,p=0.08),NT(3.31±0.22vs.3.30±0.23mm,p=0.24)和PCS(0.42±0.19vs.0.43±0.16mm,p=0.79)。
结论:存在老年性皮质,核,后囊下白内障对LT无影响,ACS,NT,和PCS。测量LT及其主要成分时应控制混杂因素。
BACKGROUND: Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of common senile cataract formation on the LT, anterior (ACS) and posterior (PCS) cortex space, and
nuclear thickness (NT), controlling for sex, age, and axial length.
METHODS: A cross-sectional study was performed. A consecutive sample of 603 volunteers (403 women, 200 men) aged 59.1 ± 18.8 years was recruited. The standardized Lens Opacification Classification System (LOCS)-III was used to classify eyes (randomly selected) into cataractous and non-cataractous groups. Also, they were classified according to the cataract location (presence or absence of cortical,
nuclear, or posterior subcapsular cataract). Optical biometry was performed to measure LT, ACS, NT, and PCS. Propensity score was used to match participants one-to-one for sex, age, and axial length. Groups were compared using the Student\'s t test or Yuen\'s test.
RESULTS: The four classifications divided unmatched eyes into: 361 cataractous lenses and 242 non-cataractous, 226 cortical and 377 non-cortical cataractous, 313 nuclear and 290 non-
nuclear cataractous and 242 subcapsular and 361 non-subcapsular cataractous. Before matching, cataractous eyes showed significantly higher LT (4.52 ± 0.39 vs. 3.94 ± 0.46 mm, p < 0.001), ACS (0.75 ± 0.20 vs. 0.58 ± 0.23 mm, p < 0.001), NT (3.34 ± 0.23 vs. 3.18 ± 0.25 mm, p < 0.001) and PCS (0.42 ± 0.19 vs. 0.37 ± 0.19 mm, p = 0.003). Matched lens, cortical,
nuclear, and subcapsular cataract samples comprised 146, 258, 182, and 226 eyes, respectively. After matching, no significant differences were observed in LT (4.34 ± 0.37 vs. 4.33 ± 0.36 mm, p = 0.94), ACS (0.72 ± 0.20 vs. 0.76 ± 0.19 mm, p = 0.08), NT (3.31 ± 0.22 vs. 3.30 ± 0.23 mm, p = 0.24) and PCS (0.42 ± 0.19 vs. 0.43 ± 0.16 mm, p = 0.79).
CONCLUSIONS: The presence of senile cortical,
nuclear, and posterior subcapsular cataract have no effect on LT, ACS, NT, and PCS. Confounding factors should be controlled for when measuring LT and its main components.