未经证实:严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)感染与持续症状有关(“长COVID”)。我们评估了聚合酶链反应(PCR)证实的SARS-CoV-2感染的非住院成人中长COVID的负担。
UNASSIGNED:在2020年秋天,对成年丹麦普通人群进行了横断面调查。这包括对SARS-CoV-2抗体进行自我管理的即时测试,简短形式健康调查(SF-12),和2019年冠状病毒病(COVID-19)相关症状问题。在调查前(病例)≥12周,SARS-CoV-2PCR检测阳性的非住院受访者与年龄的血清阴性对照相匹配(1:10),性别,和体重指数。估计每个健康结果的倾向得分加权比值比(OR)和危险因素的OR。
未经批准:总共,包括742例病例和7420例对照。至少1例长COVID症状的归因风险为每100例25.0例(95%置信区间[CI],22.2-27.4).与对照组相比,病例报告总体健康状况较差(或,5.9[95%CI,5.0-7.0]),并且对广泛的症状有更高的几率,特别是味觉丧失(或,11.8[95%CI,9.5-14.6])和气味(OR,11.2[95%CI,9.1-13.9])。身体和心理成分汇总得分也显着降低,差异为-2.5(95%CI,-3.1至-1.8)和-2.0(95%CI,-2.7至-1.2),分别。女性性别和初次感染的严重程度是长期COVID的主要危险因素。
UNASISIGNED:非住院SARS-CoV-2PCR阳性个体的身心健康显着下降,4人中有1人报告至少1例长COVID症状持续存在。
UNASSIGNED: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with persistent symptoms (\"long COVID\"). We assessed the burden of long COVID among nonhospitalized adults with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection.
UNASSIGNED: In the fall of 2020, a cross-sectional survey was performed in the adult Danish general population. This included a self-administered point-of-care test for SARS-CoV-2 antibodies, the Short Form Health Survey (SF-12), and coronavirus disease 2019 (COVID-19)-associated symptom questions. Nonhospitalized respondents with a positive SARS-CoV-2 PCR test ≥12 weeks before the survey (cases) were matched (1:10) to seronegative controls on age, sex, and body mass index. Propensity score-weighted odds ratios (ORs) and ORs for risk factors were estimated for each health outcome.
UNASSIGNED: In total, 742 cases and 7420 controls were included. The attributable risk of at least 1 long-COVID symptom was 25.0 per 100 cases (95% confidence interval [CI], 22.2-27.4). Compared to controls, cases reported worse general health (OR, 5.9 [95% CI, 5.0-7.0]) and had higher odds for a broad range of symptoms, particularly loss of taste (OR, 11.8 [95% CI, 9.5-14.6]) and smell (OR, 11.2 [95% CI, 9.1-13.9]). Physical and Mental Component Summary scores were also significantly reduced with differences of -2.5 (95% CI, -3.1 to -1.8) and -2.0 (95% CI, -2.7 to -1.2), respectively. Female sex and severity of initial infection were major risk factors for long COVID.
UNASSIGNED: Nonhospitalized SARS-CoV-2 PCR-positive individuals had significantly reduced physical and mental health, and 1 in 4 reported persistence of at least 1 long-COVID symptom.