NKX2.5是一种在心血管生长发育中起关键作用的转录因子。先前已经进行了一些独立的研究来研究NKX2.5编码区域中的单核苷酸多态性(SNP)606G>C(rs3729753)与先天性心脏病(CHD)之间的关联。然而,这些研究的结果不一致.因此,本研究旨在通过荟萃分析揭示NKX2.5SNP606G>C与中国人群冠心病风险之间的关系。在PubMed中检索相关文章后,MEDLINE,EMBASE,WebofScience,科克伦,中国国家知识基础设施,万方数据,和VIP数据库直到2021年8月,共有8项研究被纳入本荟萃分析.然后将合格的研究数据合并为等位基因,支配,隐性,杂合子,纯合子,和加法模型。当前荟萃分析的总体结果表明,在任何模型中,606G>C与中国人群的冠心病无关。此外,基于CHD类型的亚组分析给出了相同的阴性结果。敏感性分析结果显示,各研究删除后无显著相关性。此外,值得注意的是,结果为阴性,异质性不显著.总之,很明显,NKX2-5SNP606G>C可能不会导致中国人群冠心病的风险。
NKX2.5 is a transcription factor that plays a key role in cardiovascular growth and development. Several independent studies have been previously conducted to investigate the association between the single-nucleotide polymorphism (SNP) 606G >C (rs3729753) in the coding region of
NKX2.5 and congenital heart disease (CHD). However, the results of these studies have been inconsistent. Therefore, the present study aimed to reveal the relationship between
NKX2.5 SNP 606G >C and the risk of CHD as possible in the Chinese population through meta-analysis. After retrieving related articles in PubMed, MEDLINE, EMBASE, Web of science, Cochrane, China National Knowledge Infrastructure, Wanfang DATA, and VIP database until August 2021, a total of eight studies were included in the present meta-analysis. The qualified research data were then merged into allele, dominant, recessive, heterozygous, homozygous, and additive models. Overall results of the current meta-analysis showed that 606G >C was not associated with CHD of the Chinese population in any model. In addition, subgroup analysis based on CHD type gave the same negative result. Results of sensitivity analysis showed that there was no significant correlation after the deletion of each study. Furthermore, it was noted that the results were negative and the heterogeneity was not significant. In conclusion, it was evident that NKX2-5 SNP 606G >C may not lead to the risk of CHD in Chinese population.