背景:云南是中国艾滋病毒感染率最高的国家。其他可治疗的性传播感染(STIs)与加速的HIV传播和不良的ART结果有关。但只能通过综合算法诊断。
方法:我们招募了406名HIV阳性参与者进行横断面研究(204名接受ART治疗,202名接受ART治疗)。收集血液样品和首次排泄的尿液样品。实时聚合酶链反应方法用于诊断沙眼衣原体(CT),淋病奈瑟菌(NG)和生殖支原体(MG)。还进行了梅毒和2型单纯疱疹病毒(HSV-2)测试。
结果:在406名参与者中,在接受ART的个体中,性传播感染的总体患病率为47.0%和45.1%,在接受ART的个体中为49.0%,分别。测试频率为11.6%(11.8%与11.4%),33.2%(29.4%与37.1%),3.2%(3.4%与3.0%),2.0%(3.4%与0.5%)和4.7%(6.4%与3.0%)为活动性梅毒,HSV-2,CT,NG和MG,分别。两组中多次感染的百分比在接受ART的参与者中为10.8%(22/204),在接受ART的参与者中为9.9%(20/202)。女性性别,年龄在18到35岁之间,曾经注射毒品,同性恋或双性恋身份,HIV/HBV合并感染,未接受ART被确定为危险因素.自我报告的无症状患者没有被排除在实验室诊断的STI之外。
结论:性传播感染患病率为47.0%(45.1%vs.49.0%),HSV-2,梅毒和MG是HIV感染者中最常见的性传播感染。我们发现在未接受ART的个体中MG的患病率很高(6.4%)。HIV阳性者往往忽视或隐藏其生殖道不适;因此,我们建议在HIV感染者中加强性传播感染联合筛查和治疗服务,无论他们是否描述生殖道不适.
BACKGROUND: Yunnan has the highest rates of HIV in China. Other treatable sexually transmitted infections (STIs) are associated with accelerated HIV transmission and poor ART outcomes, but are only diagnosed by syndromic algorithms.
METHODS: We recruited 406 HIV-positive participants for a cross-sectional study (204 ART-naive and 202 receiving ART). Blood samples and first-voided urine samples were collected. Real-time polymerase chain reaction methods were used for diagnosing Chlamydia trachomatis (CT), Neisseria gonorrhea (
NG) and Mycoplasma genitalium (MG). Syphilis and herpes simplex virus type 2 (HSV-2) tests were also performed.
RESULTS: Among the 406 participants, the overall prevalence of STIs was 47.0% and 45.1% in ART-naive individuals and 49.0% in individuals receiving ART, respectively. The testing frequencies were 11.6% (11.8% vs. 11.4%), 33.2% (29.4% vs. 37.1%), 3.2% (3.4% vs. 3.0%), 2.0% (3.4% vs. 0.5%) and 4.7% (6.4% vs. 3.0%) for active syphilis, HSV-2, CT,
NG and MG, respectively. The percentage of multiple infections in both groups was 10.8% (22/204) in ART-naive participants and 9.9% (20/202) in participants receiving ART. Female sex, an age between 18 and 35 years, ever injecting drugs, homosexual or bisexual status, HIV/HBV coinfection, and not receiving ART were identified as risk factors. Self-reported asymptomatic patients were not eliminated from having a laboratory-diagnosed STI.
CONCLUSIONS: The STI prevalence was 47.0% (45.1% vs. 49.0%), and HSV-2, syphilis and MG were the most common STIs in HIV-infected individuals. We found a high prevalence (6.4%) of MG in ART-naive individuals. HIV-positive individuals tend to neglect or hide their genital tract discomfort; thus, we suggest strengthening STI joint screening and treatment services among HIV-infected individuals regardless of whether they describe genital tract discomfort.