背景:低于或高于医学研究所建议的妊娠体重增加与不良围产期和新生儿结局相关。很少有研究评估血清和红细胞叶酸浓度与青少年妊娠期体重增加之间的关系。此外,怀孕期间锌缺乏与免疫力受损有关,长时间的劳动,早产和早产,宫内生长受限,低出生体重,和妊娠高血压.
目的:我们研究的目的是评估血清锌浓度之间的关联,血清叶酸,和红细胞叶酸,随着来自墨西哥城的一组青少年母亲的妊娠体重以及新生儿的体重和身长的增加。
结果:在我们的研究中,406名青春期新生儿参加了比赛。青少年的平均年龄为15.8岁。主要社会经济水平为中低(57.8%),单身(57%),89.9%从事家庭活动,41.3%完成了中学教育。在36.7%的病例中观察到妊娠体重增加过多,而妊娠体重增加不足的占38.4%。在20.9%的样本中观察到小于胎龄的婴儿。低血清叶酸(OR2.1,95%CI1.3-3.3),红细胞叶酸降低(OR1.6,95%CI1.0-2.6),血清锌浓度降低(OR3.3,95%CI2.1-5.2)与妊娠期体重增加不足相关.血清锌水平降低(OR1.2,95%CI1.2-3.4)与分娩胎龄小的婴儿的可能性增加有关。
结论:低血清叶酸,红细胞叶酸,血清锌浓度与妊娠体重增加和胎龄较小的婴儿有关。妊娠期体重增加过多和不足,以及有一个小胎龄婴儿,在青春期的母亲中很常见。
BACKGROUND: Gestational weight gain below or above the Institute of Medicine recommendations has been associated with adverse perinatal and neonatal outcomes. Very few studies have evaluated the association between serum and red blood cell folate concentrations and gestational weight gain in adolescents. Additionally, zinc deficiency during pregnancy has been associated with impaired immunity, prolonged labor, preterm and post-term birth, intrauterine growth restriction, low birth weight, and pregnancy-induced hypertension.
OBJECTIVE: The purpose of our study is to evaluate the association between serum concentrations of zinc, serum folate, and red blood cell folate, with the increase in gestational weight and the weight and length of the newborn in a group of adolescent mothers from Mexico City.
RESULTS: In our study, 406 adolescent-neonate dyads participated. The adolescents\' median age was 15.8 years old. The predominant socioeconomic level was middle-low (57.8%), single (57%), 89.9% were engaged in home activities, and 41.3% completed secondary education. Excessive gestational weight gain was observed in 36.7% of cases, while insufficient gestational weight gain was noted in 38.4%. Small for gestational age infants were observed in 20.9% of the sample. Low serum folate (OR 2.1, 95% CI 1.3-3.3), decreased red blood cell folate (OR 1.6, 95% CI 1.0-2.6), and reduced serum zinc concentrations (OR 3.3, 95% CI 2.1-5.2) were associated with insufficient gestational weight gain. Decreased serum zinc levels (OR 1.2, 95% CI 1.2-3.4) were linked to an increased probability of delivering a baby who is small for their gestational age.
CONCLUSIONS: Low serum folate, red blood cell folate, and serum zinc concentrations were associated with gestational weight gain and having a small gestational age baby. Both excessive and insufficient gestational weight gain, as well as having a small gestational age baby, are frequent among adolescent mothers.