■与Delta变体相比,Omicron变体的致病性较弱,但传染性很强,老年危重患者占大多数。本研究对指导临床个性化治疗和有效利用医疗资源具有重要意义。
■这项研究的重点是157名感染新型冠状病毒Omicron变种的患者,从12月起,2022年2月,2023年。目的是分析基线数据,测试结果,影像学检查结果并确定与严重疾病相关的危险因素。
■在纳入的157名患者中,非重症组55例(均为中度),重症组102例(包括重症和危重症).Omicron变异体感染在非重症病例和重症病例之间表现出显着差异(基线数据,血常规,凝血,炎症标志物,心脏,肝脏,肾功能,胸部CT,VTE得分,等。).多因素logistic回归分析显示中性粒细胞百分比>75%,嗜酸性粒细胞百分比<0.4%,D-二聚体>0.55mg/L,PCT>0.25ng/mL,LDH>250U/L,白蛋白<40g/L,A/G比值<1.2,胆碱酯酶<5100U/L,尿酸>357mol/L和血钙<2.11mmol/L是新型冠状病毒感染最可能的独立危险因素。
■高龄,低氧合指数,中性粒细胞百分比升高,嗜酸性粒细胞百分比降低,PCT升高,LDH升高,白蛋白减少,A/G比降低,尿酸升高,血钙减少,D-二聚体升高是非重症患者进展为重症的独立预后危险因素。应密切监测和积极治疗这些因素,以预防或尽量减少严重疾病的发生。
The Omicron variant has a weaker pathogenicity compared to the Delta variant but is highly transmissible and elderly critically ill patients account for the majority. This study has significant implications for guiding clinical personalized treatment and effectively utilizing healthcare resources.
The study focuses on 157 patients infected with the novel coronavirus Omicron variant, from December, 2022, to February, 2023. The objective is to analyze the baseline data, test results, imaging findings and identify risk factors associated with severe illness.
Among the 157 included patients, there were 55 cases in the non-severe group (all were moderate cases) and 102 cases in the severe group (including severe and critical cases). Infection with the Omicron variant exhibits significant differences between non-severe and severe cases (baseline data, blood routine, coagulation, inflammatory markers, cardiac, liver, kidney functions, Chest CT, VTE score, etc.). A multifactorial logistic regression analysis showed that neutrophil percentage >75%, eosinophil percentage <0.4%, D-dimer >0.55 mg/L, PCT >0.25 ng/mL, LDH >250 U/L, albumin <40 g/L, A/G ratio <1.2, cholinesterase<5100 U/L, uric acid >357 mole/L and blood calcium<2.11 mmol/L were the most likely independent risk factors for severe novel coronavirus infection.
Advanced age, low oxygenation index, elevated neutrophil percentage, decreased eosinophil percentage, elevated PCT, elevated LDH, decreased albumin, decreased A/G ratio, elevated uric acid, decreased blood calcium, and elevated D-dimer are independent prognostic risk factors for non-severe patients progressing to severe illness. These factors should be closely monitored and actively treated to prevent or minimize the occurrence of severe illness.