目的:我们进行了一项荟萃分析,以确定高氧对健康个体和心脏代谢性疾病患者肌肉交感神经活动的影响。
方法:对电子数据库进行全面搜索,直至2022年8月。所有研究设计(评论除外)都包括:人群(人类;明显健康或患有至少一种慢性疾病);暴露(高氧或肥大时的肌肉交感神经活动);比较(高氧或肥大与常氧);和结果(肌肉交感神经活动,心率,血压,分钟通风)。49项研究最终纳入荟萃分析。
结果:在健康个体中,高氧对交感神经阵发频率没有影响(平均差[MD]-1.07阵发/分钟;95%置信区间[CI]-2.17,0.04阵发/分钟;P=0.06),爆发发生率(MD0.27爆发/100心跳[hb];95%CI-2.10,2.64爆发/100hb;P=0.82),脉冲串振幅(P=0.85),或总活动(P=0.31)。在那些患有慢性病的人中,高氧降低了爆发频率(MD-5.57爆发/分钟;95%CI-7.48,-3.67爆发/分钟;P<0.001)和爆发发生率(MD-4.44爆发/100hb;95%CI-7.94,-0.94爆发/100hb;P=0.01),但对爆发幅度(P=0.36)或总活动(P=0.90)没有影响。我们的荟萃回归分析确定了常氧爆发频率与高氧爆发频率变化之间的反比关系。在这两组中,高氧会降低心率,但对任何血压测量均无影响。
结论:高氧不会改变健康人的交感神经活动。相反,在那些患有慢性疾病的人中,高氧会降低交感神经活动。无论疾病状况如何,静息交感神经突发频率预测突发频率的变化程度,对于休息活动较高的人来说,下降幅度更大。
OBJECTIVE: We conducted a meta-analysis to determine the effect of hyperoxia on muscle sympathetic nerve activity in healthy individuals and those with cardio-metabolic diseases.
METHODS: A comprehensive search of electronic databases was performed until August 2022. All study designs (except reviews) were included: population (humans; apparently healthy or with at least one chronic disease); exposures (muscle sympathetic nerve activity during hyperoxia or hyperbaria); comparators (hyperoxia or hyperbaria vs. normoxia); and outcomes (muscle sympathetic nerve activity, heart rate, blood pressure, minute ventilation). Forty-nine studies were ultimately included in the meta-analysis.
RESULTS: In healthy individuals, hyperoxia had no effect on sympathetic burst frequency (mean difference [MD] - 1.07 bursts/min; 95% confidence interval [CI] - 2.17, 0.04bursts/min; P = 0.06), burst incidence (MD 0.27 bursts/100 heartbeats [hb]; 95% CI - 2.10, 2.64 bursts/100 hb; P = 0.82), burst amplitude (P = 0.85), or total activity (P = 0.31). In those with chronic diseases, hyperoxia decreased burst frequency (MD - 5.57 bursts/min; 95% CI - 7.48, - 3.67 bursts/min; P < 0.001) and burst incidence (MD - 4.44 bursts/100 hb; 95% CI - 7.94, - 0.94 bursts/100 hb; P = 0.01), but had no effect on burst amplitude (P = 0.36) or total activity (P = 0.90). Our meta-regression analyses identified an inverse relationship between normoxic burst frequency and change in burst frequency with hyperoxia. In both groups, hyperoxia decreased heart rate but had no effect on any measure of blood pressure.
CONCLUSIONS: Hyperoxia does not change sympathetic activity in healthy humans. Conversely, in those with chronic diseases, hyperoxia decreases sympathetic activity. Regardless of disease status, resting sympathetic burst frequency predicts the degree of change in burst frequency, with larger decreases for those with higher resting activity.