癫痫是一种复杂的神经系统疾病,其特征不仅在于癫痫发作,还在于显著的神经精神合并症。影响大约三分之一的确诊患者。这篇综述探讨了癫痫与其相关的精神和认知障碍之间的复杂关系。注重炎症的作用。最近对癫痫的定义强调其多面性,把它和神经生物学联系起来,精神病学,认知,社会赤字。炎症已成为影响癫痫患者癫痫发作活动和神经精神结局的关键因素。本文严格研究了失调的炎症途径如何破坏神经递质传递并导致抑郁症。情绪障碍,和焦虑在癫痫患者中普遍存在。它还评估了当前的治疗方法,并强调了抗炎疗法在治疗癫痫和相关神经精神疾病方面的潜力。此外,该综述强调了抗癫痫药物抗炎作用的重要性,抗抑郁药,和抗精神病药及其对情绪障碍的治疗意义。此外,简要介绍了生酮饮食在治疗癫痫及其精神病合并症中的作用。此外,它简要讨论了肠-脑轴在维持神经系统健康中的作用,以及其失调与癫痫的关系。该综述得出结论,炎症在将癫痫与其神经精神合并症联系起来中起着关键作用。提示有针对性的抗炎干预可能提供有希望的治疗策略.未来的研究应集中于纵向研究,比较有和没有神经精神合并症的癫痫患者的预后。诊断工具的开发,以及探索新型抗炎治疗以更好地管理这些复杂的相互作用。
Epilepsy is a complex neurological disorder characterized not only by seizures but also by significant
neuropsychiatric comorbidities, affecting approximately one-third of those diagnosed. This review explores the intricate relationship between epilepsy and its associated psychiatric and cognitive disturbances, with a focus on the role of inflammation. Recent definitions of epilepsy emphasize its multifaceted nature, linking it to neurobiological, psychiatric, cognitive, and social deficits. Inflammation has emerged as a critical factor influencing both seizure activity and
neuropsychiatric outcomes in epilepsy patients. This paper critically examines how dysregulated inflammatory pathways disrupt neurotransmitter transmission and contribute to depression, mood disorders, and anxiety prevalent among individuals with epilepsy. It also evaluates current therapeutic approaches and underscores the potential of anti-inflammatory therapies in managing epilepsy and related
neuropsychiatric conditions. Additionally, the review highlights the importance of the anti-inflammatory effects of anti-seizure medications, antidepressants, and antipsychotics and their therapeutic implications for mood disorders. Also, the role of ketogenic diet in managing epilepsy and its psychiatric comorbidities is briefly presented. Furthermore, it briefly discusses the role of the gut-brain axis in maintaining neurological health and how its dysregulation is associated with epilepsy. The review concludes that inflammation plays a pivotal role in linking epilepsy with its
neuropsychiatric comorbidities, suggesting that targeted anti-inflammatory interventions may offer promising therapeutic strategies. Future research should focus on longitudinal studies comparing outcomes between epileptic patients with and without
neuropsychiatric comorbidities, the development of diagnostic tools, and the exploration of novel anti-inflammatory treatments to better manage these complex interactions.