■牙源性囊肿有转化为肿瘤的潜力。然而,转化为肿瘤组织的特征尚未得到很好的描述,这种现象的确切原因尚不清楚。
■本研究旨在描述转化为肿瘤的牙源性囊肿的特征,并寻找其潜在的病因。
■在PubMed中索引的英文书面研究,科学直接,和Proquest使用由医学主题词验证的关键词进行评估:“牙源性囊肿”和“肿瘤细胞转化”。
■系统评价和荟萃分析(PRISMA)指南的首选报告项目被用作指南。
■按照PRISMA指南中的步骤,对19篇文章进行了全面审查(3例病例系列和16例病例报告),其中27名受试者为15至86岁的男性16人(59%)和女性11人(41%)。
■囊性起源是八个牙质囊肿,四个牙源性角化囊肿,两个残余囊肿,一个根性囊肿,一个钙化牙源性囊肿,一个滤泡囊肿,一个腺性牙源性囊肿,9个未明确的牙源性囊肿转化为成釉细胞瘤(3例)和癌(24例)。
■牙源性囊肿的肿瘤转化是由于牙源性囊肿去除不充分的上皮残留和感染引起的慢性炎症引起的。然而,他们转变的确切原因仍不清楚。
■因此,仔细切除牙源性囊肿和术后定期随访是预防复发和肿瘤转化的关键.需要进一步的研究来研究牙源性囊肿肿瘤转化的潜在原因。
UNASSIGNED: Odontogenic cysts have the potential to transform into neoplasms. However, the characteristics of those which transformed to neoplastic tissues have not been well described and the exact causes of that phenomenon are not yet clear.
UNASSIGNED: This study aims to describe characteristics of odontogenic cysts that transformed into neoplasms and to look for their potential etiologies.
UNASSIGNED: English-written studies indexed in PubMed, Science Direct, and Proquest were assessed using keywords verified by Medical Subject Headings: \'Odontogenic Cyst\' and \'Neoplastic Cell Transformation\'.
UNASSIGNED: Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines were used as guidance.
UNASSIGNED: Following steps in PRISMA guidelines, 19 articles were fully reviewed (three case series and 16 case reports) with 27 subjects of 16 males (59%) and 11 females (41%) from 15 to 86 years old.
UNASSIGNED: Cystic origins were eight dentigerous cysts, four odontogenic keratocysts, two residual cysts, one radicular cyst, one calcifying odontogenic cyst, one follicular cyst, one glandular odontogenic cyst, and nine unspecified odontogenic cysts that transformed to ameloblastoma (3 cases) and carcinoma (24 cases).
UNASSIGNED: Neoplastic transformations of odontogenic cysts arose from epithelial remnants of inadequate odontogenic cyst removal and chronic inflammation due to infection. However, the exact causes of their transformations remain unclear.
UNASSIGNED: Therefore, careful removal of odontogenic cysts and regular postoperative follow-ups are key to prevent recurrence and neoplastic transformation. Future studies are needed to investigate potential causes of neoplastic transformation of odontogenic cysts.