背景:尽管遗传咨询和检测有好处,癌症遗传服务的摄取普遍较低,黑人/非裔美国人(黑人)女性与非西班牙裔白人女性相比,接受遗传服务的可能性大大降低。我们的团队开发了一种文化敏感的,叙事决策辅助视频,以促进有遗传性乳腺癌综合征风险的黑人女性接受遗传咨询,可将其与临床环境中基于人群的癌症风险评估结合起来.我们在这里报告了一项试点研究,以证明获得遗传咨询和干预满意度的意图发生变化。
方法:在乳房X线照片检查时,招募个人未受乳腺癌影响的黑人女性,并根据家族史筛查在乳房X线照相术中心进行遗传咨询。一个潜在的,事后调查研究设计,在理论建构的指导下,用于评估基线和即时干预后的社会心理因素,包括意向参与遗传咨询和干预满意度。
结果:达到了试点招募目标(n=30)。干预前,50%的参与者表示他们极有可能进行遗传咨询预约,与干预后的70%相比(p=0.05)。看完干预后,50%的参与者表示,该视频改变了他们对遗传咨询的看法。
结论:这项研究证明了文化对决策辅助干预的满意度,该干预旨在激发患有遗传性乳腺癌风险的黑人女性参加遗传咨询预约。我们的研究表明,意图可能是旨在支持遗传服务决策的干预措施的特定和关键结构。研究结果为后续大规模的设计提供了信息,随机实施研究。
背景:试验注册:Clinicaltrials.govNCT04082117。2019年9月9日注册。追溯登记。
BACKGROUND: Despite the benefits of genetic counseling and testing, uptake of cancer genetic services is generally low and Black/African American (Black) women are substantially less likely to receive genetic services than non-Hispanic White women. Our team developed a culturally sensitive, narrative decision aid video to promote uptake of genetic counseling among Black women at risk for a hereditary breast cancer syndrome that can be incorporated in conjunction with population-based cancer risk assessment in a clinical setting. We report here a pilot study to demonstrate changes in intention to access genetic counseling and intervention satisfaction.
METHODS: Black women who were personally unaffected by breast cancer and were recommended for genetic counseling based on family history screening in a mammography center were recruited at the time of the mammogram. A prospective, pre-post survey study design, guided by theoretical constructs, was used to evaluate baseline and immediate post-intervention psychosocial factors, including intention to participate in genetic counseling and intervention satisfaction.
RESULTS: Pilot recruitment goals were met (n = 30). Pre-intervention, 50% of participants indicated that they were extremely likely to make a genetic counseling appointment, compared with 70% post-intervention (p = 0.05). After watching the intervention, 50% of participants indicated that the video changed their mind regarding genetic counseling.
CONCLUSIONS: This study demonstrated cultural satisfaction with a decision aid intervention designed to motivate Black women with hereditary breast cancer risk to attend a genetic counseling appointment. Our study showed that intention may be a specific and key construct to target in interventions designed to support decision-making about genetic services. Study results informed the design of a subsequent large scale, randomized implementation study.
BACKGROUND: Trial registration: Clinicaltrials.gov NCT04082117 . Registered September 9, 2019. Retrospectively registered.