利什曼病是一种广泛的疾病,每年导致20,000至30,000人死亡,使其成为流行地区的主要健康问题。因为低性能的药物,给药对利什曼病的更好治疗提出了巨大的挑战。本研究的目的是综述纳米颗粒作为利什曼病治疗新方法的应用。为了确定所有相关文献,我们搜索了WebofSciences,Scopus,PubMed,NCBI,Scielo,和谷歌学者,以及1986年至2019年发表的概述研究。在本研究中,我们试图在不同的条件下确定不同的研究工作,以检查各种纳米颗粒对不同形式的利什曼病的影响。这样,我们可以比较他们的结果,并从有关该主题的最新研究中获得可靠的结论。我们的审查结果表明,纳米粒子与化学药物的结合提高了质量,效率,和药物的可持续性,并降低其成本。最后,考虑到使用纳米粒子来破坏寄生虫,它们的抑制作用(使药物更有效,危害更小),以及它们在制造有效疫苗以预防和对抗寄生虫方面的效用,强烈建议进一步研究这个问题。
Leishmaniasis is a widespread disease that causes 20,000 to 30,000 deaths annually, making it a major health problem in endemic areas. Because of low-performance medications, drug delivery poses a great challenge for better treatment of leishmaniasis. The present study\'s purpose was to review the application of nanoparticles as a new method in leishmaniasis treatment. To identify all relevant literature, we searched Web of Sciences, Scopus, PubMed, NCBI, Scielo, and Google Scholar, and profiled studies published between 1986 and 2019. In the present study, we tried to identify different research efforts in different conditions that examined the influence of various nanoparticles on different forms of leishmaniasis. In this way, we could compare their results and obtain a reliable conclusion from the most recent studies on this subject. Our review\'s results indicate that incorporating nanoparticles with chemical drugs improves the quality, efficiency, and sustainability of drugs and reduces their costs. Finally, considering the use of nanoparticles in the destruction of parasites, their inhibitory effect (making drugs more effective and less harmful), and their utility in making effective vaccines to prevent and fight against parasites, further research on this issue is highly recommended.