■重叠综合征(OS)是一组符合两个或多个CTD标准的系统性结缔组织疾病(CTD)。在这项研究中,我们评估了临床,实验室,硬皮病OS(SSc-OS)及其亚组的毛细血管镜表现以及与有限SSc(LcSSc)患者相比的随访进展。
■在一项为期10年的横断面研究中,我们评估了135例具有相同皮肤评分的成人患者(70例SSc-OS和65例LcSSc)的基线和随访临床,实验室,高分辨率胸部体层摄影术(HRCT),超声心动图,和甲褶毛细血管镜数据并进行比较。
■在135名患者中,70有SSc-OS,包括45例(64.3%)SSc-SS(干燥综合征),11(15.7%)SSc-RA(类风湿性关节炎),9例(12.9%)SSc-肌炎和5例(1.7%)SSc-SLE(系统性红斑狼疮),65人患有LcSSc。两组之间的肺和心脏受累和肺动脉高压(PAH)没有差异(p>0.05)。毛细血管镜检查的肌肉骨骼受累和非特异性模式较高(p=0.035和p=0.001),SSc-OS组的数字溃疡(DU)和硬皮病模式较低(p=0.000)。两组患者的毛细血管镜检查方式与脏器受累无明显关系(p值>0.05)。在随访(3.71±2.63年)中,新的DU和肺受累的进展(p=0.002)以及SSc-OS中毛细血管镜模式的进展较低(p=0.000).在后续行动中,在SSc-OS中没有看到新的DU,肺部受累的进展较低,皮肤评分,和毛细血管损伤。
■在SSc-OS患者中,最常见的亚组是SSc-SS。硬皮病OS与LcSSc相比,主要器官受累和毛细血管镜检查进展较低。SSc-OS患者的主要器官受累明显低于LcSSc患者。在后续行动中,在肺受累进展较低的SSc-OS中未发现新的DU,皮肤评分,和毛细血管损伤。
UNASSIGNED: Overlap syndrome (OS) is a group of systemic connective tissue diseases (CTDs) that meet the criteria of two or more CTDs. In this study, we evaluated clinical, laboratory, and capillaroscopic manifestations of patients with scleroderma OS (SSc-OS) and its subgroups and follow-up progression compared to patients with limited SSc (LcSSc).
UNASSIGNED: In a 10-year cross-sectional study, we evaluated 135 adult patients (70 with SSc-OS and 65 with LcSSc) with the same skin score for their baseline and follow-up clinical, laboratory, high-resolution chest tomography (HRCT), echocardiography, and nailfold capillaroscopy data and compared them.
UNASSIGNED: Of the 135 patients, 70 had SSc-OS, including 45 (64.3%) cases of SSc-SS (Sjögren\'s syndrome), 11 (15.7%) of SSc-RA (rheumatoid arthritis), 9 (12.9%) of SSc-myositis and 5 (1.7%) of SSc-SLE (systemic lupus erythematosus), and 65 had LcSSc. Lung and heart involvement and pulmonary arterial hypertension (PAH) did not differ between the two groups (p > 0.05). Musculoskeletal involvement and non-specific pattern of capillaroscopy were higher (p = 0.035 and p = 0.001), and digital ulcer (DU) and scleroderma patterns of capillaroscopy were lower in the SSc-OS group (p = 0.000).No significant relationship was found between capillaroscopic patterns and organ involvement in the two groups (p-value > 0.05). In the follow-up (3.71 ±2.63 years), new DU and progression of lung involvement (p = 0.002) and the progression in capillaroscopic patterns was lower in SSc-OS (p = 0.000). In the follow-up, new DU was not seen in the SSc-OS, with lower progression of lung involvement, skin score, and capillary damage.
UNASSIGNED: In SSc-OS patients, the most common subgroup was SSc-SS. Scleroderma OS was associated with lower major organ involvement and capillaroscopy progression than LcSSc. Major organ involvement in patients with SSc-OS was significantly lower than in LcSSc patients. In the follow-up, new DU was not seen in the SSc-OS with lower progression of lung involvement, skin score, and capillary damage.