■重症肌无力(MG)患者,一种影响神经肌肉接头的自身免疫性疾病,在不同的研究中,COVID-19感染率不同。这项系统评价和荟萃分析旨在评估MG患者COVID-19感染的汇总患病率。
■我们系统地搜索了PubMed,Scopus,EMBASE,WebofScience,谷歌学者,灰色文学,包括对2021年10月之前发表的研究的参考。参与者的总数,第一作者,出版年,原产国,MG患者的数量,他们的症状,住院率,和死亡全部提取作为研究数据。
■我们的文献搜索产生了253篇文章,其中75个在删除重复项后仍然存在。最后,18篇文章纳入荟萃分析。MG病例中COVID-19感染的合并患病率为2%(95%CI,1%,3%;I2=85%,P<0.001)。此外,COVID-19感染者的住院总患病率为43%(95%CI,26%,60%;I2=97.6%;P<0.001),MG加重的合并患病率为33%(95%CI,20%,46%;I2=92.6%;P<0.001)。
■总之,这项系统评价和荟萃分析显示,MG患者COVID-19感染的合并患病率为2%.
UNASSIGNED: Patients with myasthenia gravis (MG), an autoimmune disease affecting the neuromuscular junction, exhibits varying rates of COVID-19 infection across different studies. This systematic review and meta-analysis aim to estimate the pooled prevalence of COVID-19 infection in individuals with MG.
UNASSIGNED: We systematically searched PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and gray literature, including references to the research published before October 2021. The total number of participants, the first author, the publication year, the country of origin, the number of MG patients, their symptoms, hospitalization rates, and deaths were all extracted as study data.
UNASSIGNED: Our literature search yielded 253 articles, of which 75 remained after removing duplicates. Finally, 18 articles were included in the meta-analysis. The pooled prevalence of COVID-19 infection in MG cases was found to be 2% (95% CI, 1%, 3%; I2=85%, P<0.001). Additionally, the pooled prevalence of hospitalization among those with COVID-19 infection was 43% (95% CI, 26%, 60%; I2=97.6%; P<0.001), and the pooled prevalence of MG exacerbation was 33% (95% CI, 20%, 46%; I2=92.6%; P<0.001).
UNASSIGNED: In summary, this systematic review and meta-analysis reveal that the pooled prevalence of COVID-19 infection in individuals with MG is 2%.