目的:以前没有比较长期COVID患者和肌能性脑脊髓炎/慢性疲劳综合征(ME/CFS)患者的幸福感和认知功能。因此,这项研究调查了患有长期COVID(~16个月病程;n=17)和ME/CFS(~16年病程;n=24)的人的幸福感和认知功能,与年龄匹配的健康对照(n=16)。
方法:使用几份问卷检查幸福感,即健康视觉模拟量表(VAS),疲劳严重程度量表(FSS),劳累后不适(PEM),匹兹堡睡眠质量指数(PSQI)欧洲生活质量-5域(EQ-5D),MRC呼吸困难,自我效能感(SELTC),爱丁堡神经症状问卷(ENS),一般焦虑症7(GAD-7),和患者健康问卷9(PHQ-9)。使用单数字模态测试(SDMT)检查认知功能,Stroop测试,和轨迹A和B。这些是通过专门为此远程数据收集构建的移动应用程序(应用程序)提供的。
结果:本调查的主要发现是,患有ME/CFS的人和患有长期COVID的人在所有幸福感和认知功能指标上通常具有可比性,但自我报告的疼痛价值更差,疲劳,劳累后不适,睡眠质量,与流动性相关的总体福祉,平时的活动,自我照顾,呼吸困难,神经症状,自我效能感,和其他健康,如焦虑和抑郁,与对照组相比。小组对认知功能测量没有影响。
结论:这些数据表明,患有长期COVID的人和患有ME/CFS的人在本文检查的幸福感指标上都有相似的损害。因此,需要针对患有ME/CFS和长期COVID的人的福祉的干预措施。
BACKGROUND: Well-being and cognitive function had not previously been compared between people with long COVID and people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Therefore, this study examined well-being and cognitive function in people with long COVID (∼16 months illness duration; n = 17) and ME/CFS (∼16 years illness duration; n = 24), versus age-matched healthy controls (n = 16).
METHODS: Well-being was examined using several questionnaires, namely the Health Visual Analogue Scale (VAS), Fatigue Severity Scale (FSS), post-exertional malaise (PEM), Pittsburgh Sleep Quality Index (PSQI), European Quality of Life-5 Domains (EQ-5D), MRC Dyspnoea, Self-Efficacy (SELTC), The Edinburgh Neurosymptoms Questionnaire (ENS), General Anxiety Disorder 7 (GAD-7) and Patient Health Questionnaire 9 (PHQ-9). Cognitive function was examined using Single Digit Modalities Test (SDMT), Stroop test and Trails A and B. These were delivered via a mobile application (app) built specifically for this remote data collection.
RESULTS: The main findings of the present investigation were that people with ME/CFS and people with long COVID were generally comparable on all well-being and cognitive function measures, but self-reported worse values for pain, fatigue, post-exertional malaise, sleep quality, general well-being in relation to mobility, usual activities, self-care, breathlessness, neurological symptoms, self-efficacy and other well-being such as anxiety and depression, compared to controls. There was no effect of group for cognitive function measures.
CONCLUSIONS: These data suggest that both people with long COVID and people with ME/CFS have similar impairment on well-being measures examined herein. Therefore, interventions that target well-being of people with ME/CFS and long COVID are required.