■包括止血在内的多个阶段,炎症,扩散,和重塑参与伤口愈合过程。近年来,纳米材料的增加扩大了伤口愈合工具的范围;然而,仍然很难同时实现四个多级程序。
■在这项研究中,合成了石墨烯-尖刺二氧化硅异质结构纳米颗粒(GS),用于伤口愈合过程中多级的程序加速。通过两种皮肤的粘附分析了GS的纳米桥效应,在革兰氏阴性大肠杆菌(E.大肠杆菌)和革兰氏阳性金黄色葡萄球菌(S.金黄色葡萄球菌)细菌,在小鼠胚胎成纤维细胞(NIH-3T3)细胞中研究了细胞增殖和迁移,并且在具有切割伤口和背部的大肠杆菌或金黄色葡萄球菌细菌感染的雌性BALB/c小鼠中检查体内伤口愈合效果。
■首先,GS对伤口的快速闭合具有很强的纳米桥作用,因为GS表面的尖刺结构有助于皮肤的粘附,促进止血阶段。第二,石墨烯在化学和物理相互作用中都表现出抗菌活性,特别是在模拟阳光照射下。第三,石墨烯在支架功能中起着重要作用,再加上GS尖尖的地形结构,加速增殖和成熟阶段。
■通过定期促进伤口愈合的每个阶段,GS结合模拟阳光照射可显著加速创面愈合。具有简单的组成和紧凑的结构,但具有多种功能,这一策略将成为开发理想的伤口愈合纳米材料的指南.
UNASSIGNED: Multiple stages including hemostasis, inflammation, proliferation, and remodeling were involved in the wound healing process. The increase in nanomaterials in recent years has extended the scope of tools for wound healing; however, it is still difficult to achieve the four
multistage procedures simultaneously.
UNASSIGNED: In this study, graphene-spiky silica heterostructured nanoparticles (GS) were synthesized for the procedural acceleration of the
multistage in wound healing process. The nanobridge effect of GS was analyzed through the adhesion of two skins, the antibacterial effect was assessed in Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) bacteria, cell proliferation and migration were investigated in mouse embryonic fibroblast (NIH-3T3) cells, and the in vivo wound healing effect was examined in female BALB/c mice with a cutting wound and E. coli or S. aureus bacteria infection on the back.
UNASSIGNED: First, GS has a strong nanobridge effect on the rapid closure of wounds because the spiky architecture on the surface of GS facilitates the adhesion of skins, promoting the hemostasis stage. Second, graphene exhibits antimicrobial activities both in chemical and physical interactions, especially under simulated sunlight irradiation. Third, graphene plays an important role in scaffolding function, together with the spiky topographical architecture of GS, accelerating the proliferation and maturation stages.
UNASSIGNED: By periodically promoting every stage of wound healing, GS combined with simulated sunlight irradiation could significantly accelerate wound healing. With a simple composition and compact structure but multiple functions, this strategy will be the guideline for the development of ideal wound-healing nanomaterials.