未经证实:动脉恶化主要是由动脉粥样硬化引起的,随着年龄的增长。然而,我们在患有非动脉粥样硬化性疾病和中小动脉病变恶化的年轻患者中观察到严重背景或病因.因此,我们的目的是确定年龄<40岁的中小动脉恶化患者的具体特征.
UNASSIGNED:我们选择了1995年至2019年入住我们部门的患者,这些患者患有中小型动脉(动脉瘤,解剖,破裂,或动脉损伤/损伤),并集中在年龄<40岁的队列上。我们检查了患者的背景或病因,包括遗传和炎症性疾病,这可能导致动脉恶化。
未经批准:因此,超过一半(54.1%)年龄<40岁的患者患有非动脉粥样硬化性共病。然而,<40岁的患者动脉病变恶化的数量高于≥40岁的患者(3.13vs.1.33病变/患者;P=0.011)。此外,对多发性动脉病变(≥3)患者的数据分析显示,年轻人群倾向于有更具体的背景或病因,特别是Ehlers-Danlos综合征和Behçet病。年龄<40岁和≥40岁患者的全因死亡率和心血管疾病相关死亡率差异无统计学意义(P分别为0.89和0.29)。
未经证实:超过50%的年龄<40岁的中小动脉恶化患者非动脉粥样硬化,特定的临床背景或病因,包括遗传和炎性疾病。此外,他们表现出更多的动脉病变比老年患者。
UNASSIGNED: Arterial deterioration is mostly caused by atherosclerosis, which progresses with age. However, we have observed serious backgrounds or etiologies in younger patients with non-atherosclerotic diseases and deterioration of small-to-medium-sized arterial lesions. Therefore, we aimed to identify the specific features of patients aged <40 years with deterioration of small-to-medium-sized arteries.
UNASSIGNED: We selected patients who were admitted to our department from 1995 to 2019 with deterioration of small-to-medium-sized arteries (aneurysms, dissection, rupture, or arterial injury/damage) and focused on the cohort aged <40 years. We examined the backgrounds or etiologies of the patients including genetic and inflammatory diseases, which might have caused the arterial deterioration.
UNASSIGNED: Consequently, more than half (54.1%) of the patients aged <40 years had non-atherosclerotic comorbid diseases. However, the number of deteriorated arterial lesions was higher in patients aged <40 years than in patients aged ≥40 years (3.13 vs. 1.33 lesion/patient; P = 0.011). Furthermore, the data analysis of patients with multiple arterial lesions (≥3) revealed that the younger population tended to have more specific backgrounds or etiologies, notably Ehlers-Danlos syndrome and Behçet\'s disease. There were no differences in the all-cause mortality and cardiovascular disease-related mortality between patients aged <40 and ≥40 years (P = 0.89 and 0.29, respectively).
UNASSIGNED: Over 50% of patients aged <40 years with deterioration of small-to-medium-sized arteries had non-atherosclerotic, specific clinical backgrounds or etiologies, including genetic and inflammatory diseases. In addition, they exhibited more arterial lesions than older patients.