自然界提供治疗物质已有数千年,有许多来自植物来源的有价值的药物。多靶标药物在各种疾病的管理中变得至关重要,包括肝脏疾病,神经系统疾病,糖尿病,和癌症。阿魏酸是一种重要的潜在治疗剂,它很容易以低成本获得,具有低毒性,副作用最小。阿魏酸通过调节各种信号转导途径如Nrf2、p38和mTOR表现出各种治疗作用。阿魏酸表现出的作用包括抗凋亡,抗氧化剂,抗炎,抗糖尿病药,抗癌,肝脏保护,心脏保护,转录因子的激活,基因的表达,酶活性的调节,和神经保护,这进一步有助于治疗各种病理生理疾病,如癌症,皮肤病,脑部疾病,糖尿病,帕金森病,老年痴呆症,缺氧,肝脏疾病,H1N1流感,和病毒感染。当前的评论集中在天然产物作为多目标化合物来源的重要性,主要关注阿魏酸及其机理,角色,和各种疾病的保护作用。
Nature has provided therapeutic substances for millennia, with many valuable medications derived from plant sources. Multitarget drugs become essential in the management of various disorders, including hepatic disorders, neurological disorders, diabetes, and carcinomas. Ferulic acid is a significant potential therapeutic agent, which is easily available at low cost, possesses a low toxicity profile, and has minimum side effects. Ferulic acid exhibits various therapeutic actions by modulation of various signal transduction pathways such as Nrf2, p38, and mTOR. The actions exhibited by ferulic acid include anti-apoptosis, antioxidant, anti-inflammatory, antidiabetic, anticarcinogenic, hepatoprotection, cardioprotection, activation of transcriptional factors, expression of genes, regulation of enzyme activity, and neuroprotection, which further help in treating various pathophysiological conditions such as cancer, skin diseases, brain disorders, diabetes, Parkinson\'s disease, Alzheimer\'s disease, hypoxia, hepatic disorders, H1N1 flu, and viral infections. The current review focuses on the significance of natural products as sources of multitarget compounds, and a primary focus has been made on ferulic acid and its mechanism, role, and protective action in various ailments.