■综合证据并对粘膜类天疱疮(OMMP)的眼部表现频率进行组合加权测量。
■系统文献综述和荟萃分析,搜索PubMed,Embase,VHL,谷歌学者。包括报告粘膜类天疱疮和眼部受累患者的文章。至少,两名审稿人独立和并行地参与了以下所有阶段;初步筛选,全文回顾,通过验证的工具评估偏差风险,和数据提取。进行了定性分析和荟萃分析。该研究先前在PROSPERO(CRD42023451844)中注册。
■35项研究符合纳入标准,包括1,439例患者和1,040只眼的定性分析。28项研究纳入荟萃分析。年龄包括60.4至75岁。女性的报告频率更高。平均诊断时间为55.1个月,通常在90%(95%CI78%;96%)伴有双侧眼部疾病。高达92%的人最常见的表现是倒车灯和内翻,其次是睑和点状角膜炎。Ankyloblepharon,持续性上皮缺损,视力障碍是较少发生的并发症。结膜活检中的直接免疫荧光阳性率为54%(95%CI43%;64%)。眼外受累非常频繁,口腔和皮肤受累最常见。
我们的系统评价和荟萃分析表明,60岁左右的患者是受影响最严重的人群,女性占优势。通常有双侧眼部受累。最常见的表现是倒车灯和内翻;尽管视力损害和持续性上皮缺损的报道较少,在可疑的OMMP中不应该忽视它们。
UNASSIGNED: To synthesize the evidence and generate a combined weighted measure on the frequency of ocular manifestations of mucous membrane pemphigoid (OMMP).
UNASSIGNED: Systematic literature review and meta-analysis, searching PubMed, Embase, VHL, and Google Scholar. Articles reporting patients with mucous membrane pemphigoid and ocular involvement were included. At least, two reviewers independently and in parallel participated in all the following phases; preliminary screening, full-text review, risk of bias assessment by validated tools, and data extraction. Qualitative analysis and meta-analysis were conducted. This study was previously registered in PROSPERO (CRD42023451844).
UNASSIGNED: Thirty-five studies met the inclusion criteria, comprising 1,439 patients and 1,040 eyes summarized in qualitative analysis. Twenty-eight studies were included in the meta-analysis. Ages included ranged from 60.4 to 75 years. Women were reported with more frequency. The mean time for diagnosis was 55.1 months, usually with bilateral ocular disease in 90% (95% CI 78%; 96%). Trichiasis and entropion were the most frequent manifestations in up to 92%, followed by symblepharon and punctate keratitis. Ankyloblepharon, persistent epithelial defects, and visual impairment were less frequent complications. Direct immunofluorescence positivity in conjunctival biopsies was 54% (95% CI 43%; 64%). Extraocular involvement was highly frequent, being oral and skin involvement the most frequently reported.
UNASSIGNED: Our systematic review and meta-analysis evidenced that patients around 60 years of age are the most affected population with a female preponderance, usually with bilateral ocular involvement. Trichiasis and entropion were the most frequent findings; although visual impairment and persistent epithelial defects were less reported, they should not be overlooked in suspected OMMP.