口腔黏膜骨膜的再生工程策略,手术后可能需要,如腭裂修复和肿瘤切除,与颌面骨相比不发达。然而,由次要意图留下的临界大小的组织缺损可导致并发症,如感染,瘘管形成,疤痕,脸中部发育不全.这篇综述描述了目前替代粘膜骨膜组织的临床实践,包括自体移植和同种异体移植。用于粘膜骨膜伤口愈合的潜在范式转变的实验再生工程策略,例如混合移植物和工程基质,也讨论了。在整个审查过程中,在临床结果的背景下概述了每种替换或再生策略的优缺点,患者的生活质量,材料的可用性,和护理费用。最后,提出了粘膜骨膜修复领域的未来研究和发展方向,重点是确定促进粘膜骨膜再生的全球可用和负担得起的解决方案。影响声明无辅助口腔粘膜骨膜伤口愈合可导致严重并发症,如感染,瘘管,疤痕,和发育异常。因此,当口腔手术发生粘膜骨缺损时,必须考虑促进伤口愈合的策略,如在腭成形术或肿瘤切除术中。新兴的粘膜骨膜组织工程策略,在这项研究中描述,有可能克服当前标准护理供体组织移植物的局限性。例如,工程粘膜骨膜生物材料的使用可以避免对组织可用性和免疫原性的担忧.此外,组织工程策略的应用可以通过提高材料的全球可负担性和可及性来改善口腔伤口护理的公平性。
Regenerative engineering strategies for the oral
mucoperiosteum, as may be needed following surgeries, such as cleft palate repair and tumor resection, are underdeveloped compared with those for maxillofacial bone. However, critical-size tissue defects left to heal by secondary intention can lead to complications, such as infection, fistula formation, scarring, and midface hypoplasia. This review describes current clinical practice for replacing mucoperiosteal tissue, including autografts and allografts. Potentially paradigm-shifting experimental regenerative engineering strategies for mucoperiosteal wound healing, such as hybrid grafts and engineered matrices, are also discussed. Throughout the review, the advantages and disadvantages of each replacement or regeneration strategy are outlined in the context of clinical outcomes, quality of life for the patient, availability of materials, and cost of care. Finally, future directions for research and development in the area of
mucoperiosteum repair are proposed, with an emphasis on identifying globally available and affordable solutions for promoting mucoperiosteal regeneration. Impact statement Unassisted oral mucoperiosteal wound healing can lead to severe complications such as infection, fistulae, scarring, and developmental abnormalities. Thus, strategies for promoting wound healing must be considered when mucoperiosteal defects are incident to oral surgery, as in palatoplasty or tumor resection. Emerging mucoperiosteal tissue engineering strategies, described in this study, have the potential to overcome the limitations of current standard-of-care donor tissue grafts. For example, the use of engineered mucoperiosteal biomaterials could circumvent concerns about tissue availability and immunogenicity. Moreover, employment of tissue engineering strategies may improve the equity of oral wound care by increasing global affordability and accessibility of materials.