背景:面部毛孔增大是皮肤的可见形貌特征,其与皮肤光老化和皮脂产生增加相关。它仍然是一个常见的皮肤病学问题,获得了大量的临床咨询。可用的治疗方式通常在单一的作用模式下运行,因此提供有限和短期的结果。
目的:本研究旨在评估非消融性单极射频(NMRF)用于泰国患者毛孔紧缩和皮脂输出减少的长期疗效和安全性。
方法:19例毛孔增大患者接受两次NMRF治疗,间隔4周。孔体积的测量,皮肤纹理,平均孔径,皮脂生产,使用Antera®3D成像系统量化皮肤弹性,用ImageJ软件进行皮肤图像分析,Sebumeter®和Cutometer®。两名皮肤科医生的临床评估是使用盲法临床照片进行的。所有客观和主观评估都是在基线时进行的,第一次治疗一个月后,以及末次治疗后1、3和6个月的随访。在每次访视期间也记录不良反应。
结果:19名受试者中有17名完成了研究方案。在第一次处理后1个月,平均孔体积从基线显著减少24%(p<0.016)。最终治疗后,孔体积每月(p<0.001)和6个月(p<0.001)持续减少34%和38%,分别。皮脂排泄同样从基线显着下降了39%(p=0.002)和36%(p<0.001),第二次治疗后3个月和6个月,分别。在两次NMRF会议之后,皮肤纹理和弹性也显著改善。孔外观的客观评估对应于主观临床评估。治疗耐受性良好,无明显副作用,比如色素沉着,纹理改变,和疤痕。
结论:NMRF对于减少孔径和皮脂产生似乎是有效和安全的,治疗结果在两个疗程后持续6个月。
Enlarged facial pores are visible topographic features of the skin that have been associated with cutaneous photoaging and increased sebum production. It has remained a common dermatologic concern, gaining a significant number of in-clinic consults. Available treatment modalities often operate on a single mode of action, consequently offering limited and short-term outcomes.
This study aimed to evaluate the long-term efficacy and safety of a nonablative monopolar radiofrequency (NMRF) for pore tightening and sebum output reduction in Thai patients.
Nineteen patients with enlarged pores underwent two sessions of NMRF treatments at 4-week intervals. The measurements of pore volume, skin texture, average pore size, sebum production, and skin elasticity were quantified using Antera® 3D imaging system, dermoscopic image analysis with ImageJ software, Sebumeter® and Cutometer®. Clinical evaluation by two dermatologists was done using blinded clinical photographs. All objective and subjective assessments were done at the baseline, a month after the first treatment, and during follow-up visits 1, 3, and 6 months after the last treatment. Adverse effects were also recorded during each visit.
Seventeen out of the 19 subjects completed the study protocol. The mean pore volume significantly reduced by 24% from the baseline at 1 month after the first treatment (p < 0.016). The pore volume continued to decrease by 34% and 38% a month (p < 0.001) and 6 months (p < 0.001) following the final treatment, respectively. Sebum excretion likewise significantly decreased from baseline by 39% (p = 0.002) and 36% (p < 0.001), 3 and 6 months after the second treatment, respectively. Skin texture and elasticity also significantly improved following two NMRF sessions. The objective assessments of the pore appearance corresponded to subjective clinical evaluations. The treatment was well-tolerated without significant side effects, such as dyspigmentation, textural alteration, and scarring.
NMRF appears to be effective and safe for the reduction of pore size and sebum production, with therapeutic outcomes persisting up to 6 months after two treatment sessions.