背景:Calycosin可能是化学治疗剂的潜在候选者,因为已经用这种天然化合物进行了一些针对多变量癌症的研究。
目的:这篇综述简要概述了先前关于calycosin对各种癌症的潜在影响及其潜在作用机制的研究。
方法:通过GoogleScholar的系统搜索检索到的数据,PubMed,科学直接,WebofScience,和Scopus通过使用关键词包括calycosin,癌症类型,抗癌机制,协同,药代动力学和常用的工具是BioRender,ChemDrawProfessional16.0和ADMETlab2.0。
结果:根据我们的评论,calycosin在自然界中是可用的,对大约15种不同类型的癌症有效。一般来说,这种化合物的抗癌机制是通过多种过程介导的,包括调节凋亡途径,细胞周期,血管生成和转移,致癌基因,酶促途径,和信号转导过程。这些研究在各种研究模型中进行,包括硅,在体外,临床前和临床模型。抗癌作用背后的分子框架靶向一些致癌和治疗性蛋白质和多个信号级联。基于纳米配制的calycosin的疗法可以制造用于将该化合物递送至目标组织以及特定器官的优异纳米载体。当与其他天然化合物和一些标准药物组合时,这种天然化合物变得非常有效。此外,正确使用该化合物可以通过多种策略逆转对现有抗癌药物的耐药性。毛黄素显示出更好的药代动力学特性,在人体中毒性较小。
结论:Calycosin作为几种癌症类型的治疗药物具有极好的潜力,应在制药市场上使用标准化学疗法之前使用。
BACKGROUND: Calycosin may be a potential candidate regarding chemotherapeutic agent, because already some studies against multivarious cancer have been made with this natural compound.
OBJECTIVE: This review elucidated a brief overview of previous studies on calycosin potential effects on various cancers and its potential mechanism of action.
METHODS: Data retrieved by systematic searches of Google Scholar, PubMed, Science Direct, Web of Science, and Scopus by using keywords including calycosin, cancer types, anti-cancer mechanism, synergistic, and pharmacokinetic and commonly used tools are BioRender, ChemDraw Professional 16.0, and ADMETlab 2.0.
RESULTS: Based on our review, calycosin is available in nature and effective against around 15 different types of cancer. Generally, the anti-cancer mechanism of this compound is mediated through a variety of processes, including regulation of apoptotic pathways, cell cycle, angiogenesis and metastasis, oncogenes, enzymatic pathways, and signal transduction process. These study conducted in various study models, including in silico, in vitro, preclinical and clinical models. The molecular framework behind the anti-cancer effect is targeting some oncogenic and therapeutic proteins and multiple signaling cascades. Therapies based on nano-formulated calycosin may make excellent nanocarriers for the delivery of this compound to targeted tissue as well as particular organ. This natural compound becomes very effective when combined with other natural compounds and some standard drugs. Moreover, proper use of this compound can reverse resistance to existing anti-cancer drugs through a variety of strategies. Calycosin showed better pharmacokinetic properties with less toxicity in human bodies.
CONCLUSIONS: Calycosin exhibits excellent potential as a therapeutic drug against several cancer types and should be consumed until standard chemotherapeutics are available in pharma markets.