■原发性颅内生殖细胞肿瘤(ICGCT)是罕见的,在组织学上分为生殖细胞瘤和非生殖细胞瘤,具有独特的预后和治疗意义。ICGCT,基本上是由于手术进入的固有困难,与颅外同行相比,构成了不同的挑战和管理内涵。这是组织学验证的ICGCT的回顾性分析,旨在评估各种临床病理特征及其对患者管理的影响。
■我们研究所的88例经组织学诊断的ICGCT病例(超过14年)形成了研究队列,并分为生殖细胞瘤和非生殖细胞肿瘤(NGGCT)。此外,根据1)肿瘤标志物(TM)水平进一步细分生殖细胞瘤,作为正常TM的生殖细胞瘤,轻微升高的TM,和显著升高的TM和2)放射学特征,具有典型放射学和非典型放射学特征的生殖细胞瘤。
■年龄≤6岁的ICGCT(P=0.049),TM升高(P=0.047),和NGGCT组织学(P<0.001)显示明显更差的结果。此外,具有明显升高的TM和某些非典型放射学特征的生殖细胞瘤显示出类似于NGGCT的预后。
■对我们最大的单一癌症中心的印度ICGCT患者队列的分析显示,年龄≤6岁,凸起的TM,某些放射学特征可以帮助临床医生克服手术取样的局限性,对组织学诊断的生殖细胞瘤有更好的预后。
UNASSIGNED: Primary intracranial germ cell tumors (ICGCTs) are rare and are histologically classified as germinomas and non-germinomatous with distinctive prognostic and therapeutic implications. ICGCTs, essentially due to the inherent difficulty of surgical access, pose different challenges and management connotations than their extracranial counterparts. This is a retrospective analysis of histologically verified ICGCTs, which was undertaken to evaluate various clinicopathological features and their implications on patient management.
UNASSIGNED: Eighty-eight histologically diagnosed cases (over 14 years) of ICGCT at our institute formed the study cohort and were classified into germinoma and non-germinomatous germ cell tumors (NGGCTs). Additionally, germinomas were further subdivided on the basis of 1) tumor marker (TM) levels, as germinoma with normal TM, mildly elevated TM, and markedly elevated TM and 2) radiology features, as germinomas with typical radiology and atypical radiological features.
UNASSIGNED: ICGCT with age ≤6 years (P = 0.049), elevated TM (P = 0.047), and NGGCT histology (P < 0.001) showed significantly worse outcomes. Furthermore, germinomas with markedly elevated TM and certain atypical radiological features showed prognosis akin to NGGCT.
UNASSIGNED: Analysis of our largest single cancer center Indian patient cohort of ICGCT shows that inclusion of age ≤6 years, raised TM, and certain radiological features may assist clinicians in overcoming the limitations of surgical sampling, with better prognostication of histologically diagnosed germinomas.