脑出血(ICH)是中风的第二常见亚型,以高死亡率和不良预后为特征。尽管有各种治疗方法,在过去的几十年中,ICH的预后改善有限.因此,因此,必须确定一种可行的ICH治疗策略.线粒体是存在于大多数真核细胞中的细胞器,并且充当有氧呼吸和能量产生的主要位点。在不利的细胞条件下,线粒体可通过开放线粒体通透性转换孔(mPTP)诱导通透性改变,最终导致线粒体功能障碍并导致各种疾病。最近的研究表明,mPTP在包括帕金森病在内的多种神经退行性疾病的病理过程中起作用。老年痴呆症,亨廷顿病,缺血性中风和缺血再灌注损伤,在其他人中。然而,关于mPTP参与特别是ICH的研究有限。因此,这项研究从氧化应激的角度全面检查了与mPTP相关的病理过程,凋亡,坏死,自噬,铁性凋亡,和其他相关机制,以阐明mPTP参与ICH的潜在机制。本研究旨在为ICH后继发性损伤的治疗提供新的见解。
Intracerebral hemorrhage (ICH) is the second most common subtype of stroke, characterized by high mortality and a poor prognosis. Despite various treatment methods, there has been limited improvement in the prognosis of ICH over the past decades. Therefore, it is imperative to identify a feasible treatment strategy for ICH. Mitochondria are organelles present in most eukaryotic cells and serve as the primary sites for aerobic respiration and energy production. Under unfavorable cellular conditions, mitochondria can induce changes in permeability through the opening of the mitochondrial permeability transition pore (mPTP), ultimately leading to mitochondrial dysfunction and contributing to various diseases. Recent studies have demonstrated that mPTP plays a role in the pathological processes associated with several neurodegenerative diseases including Parkinson\'s disease, Alzheimer\'s disease, Huntington\'s disease, ischemic stroke and ischemia-reperfusion injury, among others. However, there is limited research on mPTP involvement specifically in ICH. Therefore, this study comprehensively examines the pathological processes associated with mPTP in terms of oxidative stress, apoptosis, necrosis, autophagy, ferroptosis, and other related mechanisms to elucidate the potential mechanism underlying mPTP involvement in ICH. This research aims to provide novel insights for the treatment of secondary injury after ICH.