目标:在美国,非西班牙裔黑人(NHB)的痴呆患病率明显高于非西班牙裔白人,潜在的风险因素可能在这种种族差异中发挥作用。我们的目标是在10年内计算年龄在50-64岁的非西班牙裔白人(NHW)和非西班牙裔黑人人群的痴呆症风险评分。并估计NHW和NHB之间分数的潜在差异。
方法:2006年至2016年的健康与退休研究用于计算心血管危险因素,衰老,和痴呆发病率(CAIDE)风险评分,预测痴呆风险的有效评分。加权平均CAIDE得分,以及可改变因素高血压的CAIDE评分,肥胖,高胆固醇血症,缺乏身体活动),和不可改变的因素(年龄,性别,教育)计算了2006-2008年、2010-2012年、2014-2016年50-64岁认知正常的成年人。检查了种族与CAIDE得分和CAIDE得分升高的关联。
结果:总共10,871名参与者被纳入分析。从2006年到2016年,NHB的CAIDE得分呈下降趋势,而从2006年到2016年,NHB的CAIDE总分和CAIDE得分始终较高,但对于不可改变的因素则没有。
结论:2006年至2016年,在美国50-64岁的成年人中,NHB的痴呆危险因素水平高于NHW,差异归因于可改变的危险因素,这有望降低痴呆症的风险。
OBJECTIVE: Non-Hispanic Black populations (NHB) have a significantly higher prevalence of dementia than non-Hispanic Whites in the U.S., and the underlying risk factors may play a role in this racial disparity. We aimed to calculate risk scores for dementia among non-Hispanic White (NHW) and non-Hispanic Black populations aged 50-64 years over a period of 10 years, and to estimate potential differences of scores between NHW and NHB.
METHODS: The Health and Retirement Study from 2006 to 2016 was used to calculate the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score, a validated score for predicting dementia risk. Weighted average CAIDE score, as well as CAIDE score for modifiable factors hypertension, obese, hypercholesterolemia, physical inactivity), and non-modifiable factors (age, sex, education) were calculated for adults aged 50-64 years with normal cognition for 2006-2008, 2010-2012, 2014-2016. The associations of race with CAIDE score and elevated CAIDE score were examined.
RESULTS: A total of 10,871 participants were included in the analysis. The CAIDE score showed declining trends for NHB from 2006 to 2016, while NHB consistently had a higher total CAIDE score and CAIDE score for modifiable factors from 2006 to 2016, but not for non-modifiable factors.
CONCLUSIONS: NHB had a higher level of dementia risk factors than NHW among adults aged 50-64 years in the U.S. from 2006 to 2016, and the difference is attributable to modifiable risk factors, which holds promise for risk reduction of dementia.