通过手术从睾丸中获得精子,并通过胞浆内精子注射技术使用这些精子,为非梗阻性无精子症(NOA)男性的生物生育开辟了道路。我们旨在通过显微解剖睾丸精子提取(micro-TESE)评估患有孤立睾丸的NOA患者的精子提取率(SRR)。在这项回顾性病例对照研究中,包括45名患有先天性或获得性孤立睾丸的NOA患者,2003年9月至2022年1月。这些患者与有双侧睾丸的NOA患者随机匹配,使用1:3的匹配比例。我们发现,孤立睾丸患者的微TESESRR与双侧睾丸的NOA患者相似(51.1%vs.50.4%)。年龄,不孕期,射精量,血清卵泡刺激素(FSH)水平,黄体生成素(LH)和睾酮,精索静脉曲张切除术的历史,睾丸固定术的历史,微TESE前的睾丸刺激治疗,睾丸体积,遗传状态,TESE侧面,Micro-TESE成功,评估两组的并发症和组织病理学评估结果,仅血清FSH和LH水平有统计学意义的差异。术后早期,两组在并发症和激素作用方面没有差异。具有孤立睾丸的NOA患者的Micro-TESE与具有双侧睾丸的NOA患者的精子回收和并发症发生率相似。
Obtaining sperm from the testis surgically and using these sperm with the intracytoplasmic sperm injection technique, has opened the way for the possibility of biological fathering in men with non-obstructive azoospermia (NOA). We aimed to evaluate our sperm retrieval rate (SRR) by
microdissection testicular sperm extraction (micro-TESE) in NOA patients with solitary testis. In this retrospective case-control study, fortyfive patients with NOA who had a congenital or acquired solitary testis were included, between September 2003 and January 2022. These patients were randomly matched with patients with NOA who had bilateral testes, using a 1:3 matching ratio. We found that SRR by micro-TESE in patients with solitary testis was similar to NOA patients with bilateral testis (51.1% vs. 50.4%). Age, infertility period, ejaculate volume, serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone, history of varicocelectomy, history of orchiopexy, testicular stimulation therapy before micro-TESE, testicular volume, genetic status, TESE side, micro-TESE success, complications and histopathological evaluation results of both groups were evaluated, there was a statistically significant difference in only serum FSH and LH levels. There was no difference between the groups in terms of complications and hormonal effects in the early postoperative period. Micro-TESE in NOA patients with solitary testis has similar sperm retrieval and complication rates as NOA patients with bilateral testis.