水凝胶是我们日常生活中最常用的材料之一,具有交联的三维网络结构,能够吸收大量流体。由于其突出的性能,比如灵活性,可调谐性,和生物相容性,水凝胶已广泛应用于生物医学研究和临床,特别是按需药物释放。然而,传统的水凝胶面临各种限制,例如,由于其高度亲水的内部环境,疏水性药物的递送。因此,已经设计和开发了含胶束的水凝胶,它具有亲水和疏水的微环境,能够储存不同的货物。基于胶束的功能,这些水凝胶可以分为胶束掺杂和化学/物理交联类型,据报道对各种刺激有反应,包括温度,pH值,辐照,电信号,磁场,等。这里,我们总结了含胶束水凝胶的研究进展,并根据我们自己实验室和其他机构的最新研究,对其在生物医学领域的应用提供了展望。
Hydrogels are one of the most commonly used materials in our daily lives, which possess crosslinked three-dimensional network structures and are capable of absorbing large amounts of fluid. Due to their outstanding properties, such as flexibility, tunability, and biocompatibility, hydrogels have been widely employed in biomedical research and clinics, especially in on-demand drug release. However, traditional hydrogels face various limitations, e.g., the delivery of hydrophobic drugs due to their highly hydrophilic interior environment. Therefore,
micelle-containing hydrogels have been designed and developed, which possess both hydrophilic and hydrophobic microenvironments and enable the storage of diverse cargos. Based on the functionalities of micelles, these hydrogels can be classified into
micelle-doped and chemically/physically crosslinked types, which were reported to be responsive to varied stimuli, including temperature, pH, irradiation, electrical signal, magnetic field, etc. Here, we summarize the research advances of
micelle-containing hydrogels and provide perspectives on their applications in the biomedical field based on the recent studies from our own lab and others.