背景:MiR-136-5p在调节发育过程以及疾病的病理生理学中起着至关重要的作用,在肿瘤抑制方面有显著的记录。
方法:本文总结了miR-136-5p在疾病中的生理和病理生理过程的最新发现。我们以miR-136-5p为关键词,在PubMed上搜索了相关研究并选择了过去五年的研究文章。
结果:MiR-136-5p代表了一类涉及各种人类疾病的microRNAs(miRNAs),包括癌症,心脑血管疾病,糖尿病,炎症性疾病,结节性硬化症,特发性肺纤维化,多囊卵巢综合征.特定疾病中miR-136-5p表达的改变导致下游基因表达失衡,影响细胞行为,例如迁移,扩散,和入侵。此外,miR-136-5p涉及五种信号通路,在许多疾病的发生和发展中至关重要。此外,它有可能促进对各种药物的耐药性。
结论:本综述旨在阐明miR-136-5p在癌症进展和非癌性疾病中的作用。强调信号通路失调。它还揭示了这种miRNA作为癌症预后生物标志物的潜力,为未来的研究提供有价值的见解和方向。
BACKGROUND: MiR-136-5p plays a vital function in regulating developmental processes as well as in the pathophysiology of diseases, with a notable record in tumor suppression.
METHODS: This article summarizes the latest findings on the physiological and pathophysiological processes of miR-136-5p in diseases. We searched for relevant studies and selected research articles from the last five years on PubMed with miR-136-5p as the keyword.
RESULTS: MiR-136-5p represents a class of microRNAs (miRNAs) that are involved in various human maladies, encompassing cancers, cardio-cerebrovascular disease, diabetes, inflammatory disease, tuberous sclerosis, idiopathic pulmonary fibrosis, and polycystic ovary syndrome. Altered expression of miR-136-5p in specific ailments results in downstream gene expression imbalance, influencing cellular behaviors, such as migration, proliferation, and invasion. Furthermore, miR-136-5p is implicated in five signaling pathways, where it is critical in the onset and advancement of a number of illnesses. Additionally, it has the potential to promote drug resistance to a variety of medications.
CONCLUSIONS: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.