■据报道,Kaffir石灰果皮油和Kaffir石灰叶油具有抗呼吸道病原体的活性。该研究的目的是开发用作第一防御口腔喷雾剂的透明口腔喷雾剂。
■制备透明抗菌口腔喷雾剂,并分析其各自的活性主要化合物,使用GC-MS。对喷雾剂进行了Gr测试。链球菌临床分离株和3种标准呼吸道病原体,使用微量肉汤稀释法。还进行了4个月的稳定性测试。
■六种透明口腔喷雾剂,三个配方由Kaffir酸橙果皮油(6、10、13%v/vKLO)和其他三个配方含有Kaffir酸橙叶油(4、8、12%v/vKLLO),是开发的。KLO中的活性化合物是α-松油醇和萜品烯-4-醇,而KLLO中的活性化合物是香茅醛。所有口腔喷雾剂均对一种A组链球菌临床分离株和三种呼吸道病原病原体具有抗菌活性,金黄色葡萄球菌ATCC29213、肺炎链球菌ATCC49619和流感嗜血杆菌ATCC49247,其中对流感嗜血杆菌ATCC49247的活性最强。所有口腔喷雾剂的抗菌活性在加速稳定性试验中保持不变,在4、30和45°C、75%相对湿度下,整个4个月的存储。
UNASSIGNED: Kaffir lime fruit peel oil and Kaffir lime leaf oil have been reported for their activities against respiratory tract pathogens. The purpose of the study was to develop clear oral sprays to be used as a first-defense oral spray.
UNASSIGNED: Clear antibacterial oral sprays were prepared and analyzed for their respective active major compounds, using GC-MS. The sprays were tested against a Gr. A streptococcal clinical isolate and 3 standard respiratory tract pathogens, using Broth microdilution method. A 4-month stability test was carried out as well.
UNASSIGNED: Six clear oral sprays, three formulae composed of Kaffir lime fruit peel oil (6, 10, 13%v/v KLO) and the other three formulae containing Kaffir lime leaf oil (4, 8, 12%v/v KLLO), were developed. The active compounds in KLO were α-terpineol and terpinene-4-ol whereas that in KLLO was citronellal. All oral sprays exhibited antibacterial activity against one Group A streptococcal clinical isolate and three respiratory pathogenic pathogens, Staphylococcus aureus ATCC 29213, Streptococcus pneumoniae ATCC 49619, and Haemophilus influenzae ATCC 49247, among which the strongest activity was against H. influenzae ATCC 49247. The antibacterial activity of all oral sprays remained unchanged in an accelerated stability test, at 4, 30, and 45 °C under 75% relative humidity, throughout the 4-month storage.